目的 優(yōu)化杏貝止咳提取物的微波干燥工藝參數(shù)。方法 以苦杏仁苷、白花前胡甲素和白花前胡乙素綜合轉(zhuǎn)移率為考察指標(biāo),選取微波功率、干燥時間、鋪盤厚度、真空度作為優(yōu)化試驗(yàn)考察因素,每個因素設(shè)計3個水平,采用L₉(3⁴)正交試驗(yàn)優(yōu)化杏貝止咳浸膏的微波干燥工藝,并與常規(guī)干燥工藝進(jìn)行比較。結(jié)果 杏貝止咳浸膏最佳微波干燥工藝為微波功率6 kW,干燥時間9 min,鋪盤厚度2~2.5 cm,真空度-0.08~-0.09 MPa。結(jié)論 該工藝高效節(jié)能,穩(wěn)定可行,為改善杏貝止咳顆粒的干燥工藝提供實(shí)驗(yàn)依據(jù)。

Objective To optimize microwave drying technology parameters of Xingbei Zhike extract by orthogonal test. Methods Comprehensive transfer rates of amygdalin, praeruptorin A, and praeruptorin B were used as index, microwave power supply. The drying time, the shop disc thickness, and the vacuum degree were selected as main factors, and every factor had three levels. L₉(3⁴) orthogonal test was used to optimize microwave drying process for Xingbei Zhike extract, and the results were compared with those of the conventional drying process. Results The optimized conditions of microwave drying process for Xingbei Zhike extract were microwave power supply 6 kW, the drying time 9 min, the shop disc thickness 2—2.5 cm, and the vacuum degree-0.08—-0.09 MPa. Conclusion The process is efficient and energy saving, stable,and feasible, which can provide evidences for improvement of drying for Xingbei Zhike Granules.

國家重大新藥創(chuàng)制科技重大專項(2013ZX09402203)