目的 優(yōu)化陶瓷膜超濾法精制金銀花水提液的工藝條件。方法 以金銀花水提液為研究對(duì)象,綠原酸轉(zhuǎn)移率為指標(biāo),選用膜孔徑、料液溫度、超濾壓力和超濾時(shí)間4個(gè)主要因素,每個(gè)因素各選取3個(gè)水平,采用L₉(3⁴)正交試驗(yàn)表進(jìn)行正交試驗(yàn)。結(jié)果 最佳優(yōu)化參數(shù):膜孔徑選擇30 nm,料液溫度選擇85 ℃,超濾壓力選擇0.18 MPa,超濾時(shí)間選擇60 min。結(jié)論 采用陶瓷膜超濾技術(shù)對(duì)金銀花水提液進(jìn)行精制的滲透量大,指標(biāo)性成分轉(zhuǎn)移率高,為陶瓷膜在中藥水提液的精制研究提供了可靠的實(shí)驗(yàn)依據(jù)。

Objective To optimize the purification conditions of Lonicerae Japonicae Flos water extract solution by ceramic membrane ultrafiltration. Methods Lonicerae Japonicae Flos water extract solution was used as object of study, and transfer rate of chlorogenic acid was investigated as indicators. The choice of membrane pore size, ultrafiltration time, ultrafiltration pressure, and ultrafiltrate temperature were selected as main factors, and three levels were established for every factor. L₉(3⁴) orthogonal test was used to optimize purification conditions. Results The optimized conditions were as following: membrane pore size 30 nm, ultrafiltration pressure 0.18 MPa, ultrafiltration temperature 85 ℃, and ultrafiltration time 60 min. Conclusion The method of purification conditions of Lonicerae Japonicae Flos water extract solution by ceramic membrane ultrafiltration has more permeation quantity and high transfer rate on index components, which provides reliable experimental basis study on purification of Chinese herbal medicine extract by ceramic membrane.