目的 比較曲克蘆丁腦蛋白水解物和腦苷肌肽治療新生兒缺氧缺血性腦病的臨床療效。方法 收集2013年1月—2015年1月在東方醫(yī)院診治的新生兒缺氧缺血性腦病患者120例,隨機(jī)分為對(duì)照組和治療組,每組各60例。對(duì)照組靜脈滴注腦苷肌肽注射液,2 mL加入到5%葡萄糖注射液50 mL中,1次/d。治療組靜脈滴注曲克蘆丁腦蛋白水解物注射液,0.5 mL/(kg·d)加入到5%葡萄糖注射液50 mL中。兩組均連續(xù)治療14 d。觀(guān)察兩組的臨床療效,同時(shí)比較兩組新生兒行為神經(jīng)(NBNA)評(píng)分、意識(shí)恢復(fù)時(shí)間、肌張力恢復(fù)時(shí)間和原始反射恢復(fù)時(shí)間。對(duì)患兒進(jìn)行6個(gè)月隨訪(fǎng),記錄兩組患兒恢復(fù)正常,發(fā)生智力低下、癲癇、腦癱的情況。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為86.67%、95.00%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組患兒治療3、7、14天NBNA評(píng)分比較差異均無(wú)統(tǒng)計(jì)學(xué)意義。治療組患兒意識(shí)恢復(fù)時(shí)間、肌張力恢復(fù)時(shí)間、原始反射恢復(fù)時(shí)間均顯著短于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療組患兒恢復(fù)率顯著高于對(duì)照組,智力低下發(fā)生率、癲癇發(fā)生率、腦癱發(fā)生率均低于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 曲克蘆丁腦蛋白水解物注射液治療新生兒缺氧缺血性腦病的臨床效果顯著,可縮短臨床恢復(fù)時(shí)間,顯著改善患兒隨訪(fǎng)結(jié)果,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To compare the clinical effect of Troxerutin and Cerebrprotein Hydrolysate Injection and Cattle Encephalon Glycoside and Ignotin Injection in treatment of neonatal hypoxic ischemic encephalopathy. Methods Patients (120 cases) with neonatal hypoxic ischemic encephalopathy in Dongfang Hospital from January 2013 to January 2015 were randomly divided into control and treatment groups, and each group had 60 cases. The patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 2 mL added into 5% Glucose Injection 50 mL, once daily. The patients in the treatment group were iv administered with Troxerutin and Cerebrprotein Hydrolysate Injection, 0.5 mL/(kg·d) added into 5% Glucose Injection 50 mL. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NBNA scores, consciousness recovery time, muscle tone recovery time and primitive reflex recovery time in two groups were compared. Two groups were follow-up for 6 months, the occurrences of back to normal, low intelligence, epilepsy, cerebral palsy in two groups were recorded. Results After treatment, the clinical efficacies in the control and treatment groups were 86.67% and 95.00%, respectively, and there were differences between two groups (P< 0.05). There was no difference between two groups about NBNA score in 3, 7, 14 day of treatment. The consciousness recovery time, muscle tone recovery time and primitive reflex recovery time in treatment was shorter than those in the control group, and there were differences between two groups (P< 0.05). The recovery rate in the treatment group was significantly higher than that in the control group, and the incidences of low intelligence, epilepsy, cerebral palsy in the treatment group were significantly lower than those in the control group, and there were differences between two groups (P< 0.05). Conclusion Troxerutin and Cerebrprotein Hydrolysate Injection has clinical curative effect in treatment of neonatal hypoxic ischemic encephalopathy, and can shorten clinical recovery time, also can significantly improve follow-up results, which has a certain clinical application value.