目的 觀察固腎安胎丸聯(lián)合鹽酸利托君治療先兆早產(chǎn)的臨床療效。方法 選擇2014年6月—2015年6月四會市婦幼保健院婦產(chǎn)科收治的先兆早產(chǎn)患者102例,隨機分為對照組和治療組,每組各51例。對照組靜脈滴注鹽酸利托君注射液,100 mg用生理鹽水500 mL稀釋,直至達到預期效果?；颊邔m縮停止后,繼續(xù)使用12 h,在停止靜脈滴注前30 min用口服鹽酸利托君片來鞏固治療。治療組在對照組基礎上口服固腎安胎丸,6 g/次,3次/d。兩組均連續(xù)治療2周。觀察兩組的保胎成功率、宮縮抑制顯效時間、累積用藥時間、孕期延長時間、自然分娩率,同時比較兩組在治療過程中的不良反應發(fā)生率。結(jié)果 治療后,對照組和治療組的保胎成功率分別為70.6%、94.1%,自然分娩率分別為43.1%、76.5%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療組宮縮抑制顯效時間、累積用藥時間均顯著短于對照組,孕期延長時間長于對照組,兩組比較差異有統(tǒng)計學意義(P<0.05)。對照組和治療組的不良反應發(fā)生率分別為29.4%、7.8%,兩組比較差異有統(tǒng)計學意義(P<0.05)。結(jié)論 固腎安胎丸聯(lián)合鹽酸利托君治療先兆早產(chǎn)具有很好的療效,能夠提高患者的保胎成功率,有利于孕婦自然分娩,具有一定的臨床推廣應用價值。

Objective To observe the clinical curative effect of Gushen Antai Pills combined with ritodrine hydrochloride in treatment of threatened premature labor. Methods Patients (102 cases) with threatened premature labor in Department of Obstetrics and Gynecology of Maternity and Child Care Hospital in Sihui City from June 2014 to June 2015 were randomly divided into control and treatment groups, and each group had 51 cases. The patients in the control group were iv administered with Ritodrine Hydrochloride Injection until the desired effect was achieved, 100 mg added into normal saline 500 mL. When the contractions stopped, Ritodrine Hydrochloride Injection was used continuously for 12 h, and the patients were po administered with Ritodrine Hydrochloride Tablets 30 min before stop the intravenous drip to consolidate therapy. The patients in the treatment group were po administered with Gushen Antai Pills on the basis of the control group, 6 g/time, three times daily. The patients in two groups were treated for 14 d. After treatment, success rate of tocolysis, contractions suppression time, cumulative duration time, prolong pregnancy time, and natural births rate in two groups were observed, at the same time, the incidence of adverse reactions in two groups during the process of treatment were compared. Results After treatment, the success rate of tocolysis in the control and treatment groups were 70.6% and 94.1%, the natural births rate in two groups were 43.1% and 76.5% respectively, and there were differences between two groups (P< 0.05). The contractions suppression time and cumulative duration time in the treatment group were shorter than those in the control group, and the prolong pregnancy time was longer than that in the control group, and there were differences between two groups (P< 0.05). The incidence of adverse reactions in control and treatment groups were 29.4% and 7.8%, respectively, and there were differences between two groups (P< 0.05). Conclusion Gushen Antai Pills combined with ritodrine hydrochloride has clinical curative effect in treatment of threatened premature labor, and can improve the patient's success rate of tocolysis, also be helpful for pregnant women to natural childbirth, which has a certain clinical application value.