姜黃素是姜黃的主要活性成分,應(yīng)用于各種疾病領(lǐng)域。研究表明,姜黃素對(duì)多個(gè)系統(tǒng)相關(guān)癌癥都具有保護(hù)效應(yīng)。其分子作用機(jī)制是通過抑制多個(gè)水平細(xì)胞的信號(hào)傳導(dǎo)途徑實(shí)現(xiàn)的。姜黃素通過與目標(biāo)分子形成黏合物直接或間接地抑制其細(xì)胞的致癌性,這些目標(biāo)分子包括轉(zhuǎn)錄因子、生長因子、酶、激酶、活性細(xì)胞激素、漿液、抗性蛋白。主要闡明了姜黃素對(duì)泌尿生殖系統(tǒng)癌癥的抗癌療效,以及其分子傳導(dǎo)途徑,為其在癌癥治療中更廣泛的應(yīng)用提供參考。

Curcumin is the main active component of Curcuma longa L., and has been used in treatment of various diseases. Studies have indicated that curcumin has protective effects on multiple organ systems. The molecular mechanism is achieved by inhibiting the signal transduction pathway of multiple levels of cells. Curcumin can inhibit the cell's activity directly or indirectly by the formation of the target molecules. These target molecules include transcription factors, growth factors, enzymes, proteins, enzymes, active cells, serum, and resistance proteins. In this paper, the effects of curcumin on the cancer of the urinary and reproductive systems, and their molecular pathways, which provide a reference for more extensive application in treatment of various carcinomas.