目的 研究小劑量人血白蛋白聯(lián)合參芎葡萄糖注射液治療急性進(jìn)展性腦梗死的療效。方法 選取天津市天津醫(yī)院2013年8月-2015年6月住院的急性進(jìn)展性腦梗死患者90例,隨機(jī)分為對(duì)照組和治療組,每組各45例。兩組均給予藥物基礎(chǔ)治療。對(duì)照組靜脈滴注參芎葡萄糖注射液100 mL/次,1次/d;治療組在對(duì)照組治療基礎(chǔ)上靜脈滴注20%人血白蛋白50 mL,1次/d。兩組患者均連續(xù)治療14 d。觀察兩組的臨床療效,比較兩組治療前后NHISS評(píng)分、Barthel指數(shù)和血液流變學(xué)。結(jié)果 治療后,對(duì)照組和治療組總有效率分別為57.78%、84.44%,兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者NIHSS評(píng)分較治療前明顯下降,Barthel指數(shù)較治療前明顯升高,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者全血黏度、血漿黏度、紅細(xì)胞比容、纖維蛋白原均較治療前明顯下降,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 小劑量人血白蛋白聯(lián)合參芎葡萄糖注射液治療急性進(jìn)展性腦梗死具有較好的臨床效果,能夠顯著降低NIHSS評(píng)分,明顯升高Barthel指數(shù),并能明顯改善患者的血液流變學(xué)指標(biāo),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of low-dose Human Albumins combined with Salivae Miltiorrhizae, Liguspyragine Hydrochloride and Glucose Injection (SGI) in treatment of acute progressing cerebral infarction.Methods Patients (90 cases) with acute progressing cerebral infarction in Tianjin Hospital from August 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 45 cases. All patient in two groups were treated with the basic therapy. Patients in the control group were iv administered with SGI, 100 mL/time, once daily. Patients in the treatment group were iv administered with 20% Human Albumins on the basis of the control group, 50 mL/time, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS score, Barthel index, and hemorheological indexes before and after treatment in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 57.78% and 84.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but Barthel indexes were significantly increased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen were significantly decreased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Low-dose Human Albumins combined with SGI has clinical curative effect in treatment of acute progressing cerebral infarction, and can significantly reduce NIHSS scores, increase Barthel indexes, obviously improve hemorheological indexes, which has a certain clinical application value.