目的 研究硫辛酸聯(lián)合精蛋白生物合成人胰島素注射液治療2型糖尿病的臨床療效。方法 選取2012年8月-2015年12月上海市閔行區(qū)龍柏社區(qū)衛(wèi)生服務(wù)中心收治的2型糖尿病患者300例,隨機分為對照組和治療組,每組各150例。對照組患者皮下注射精蛋白生物合成人胰島素注射液,初次為0.4 U/kg,2次/d分別是每日早晚餐前,以后根據(jù)患者的治療狀況確定注射劑量的增減。治療組在對照組的基礎(chǔ)上靜脈注射硫辛酸注射液,0.6 g加入生理鹽水250 mL,1次/d。兩組均連續(xù)治療1個月。觀察兩組胰島素用量情況,比較治療前后兩組空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血紅蛋白(HbA1c)、生活質(zhì)量評分的變化。結(jié)果 治療組的胰島素注射劑量在早、晚餐前,全天用量均顯著低于對照組,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組患者FBG、2 h PBG、HbA1c均較治療前顯著降低,同組治療前后差異具有統(tǒng)計學意義(P<0.05);治療后治療組這些觀察指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組患者承受壓力評分、社會關(guān)系評分、營養(yǎng)狀況評分、運動狀況評分均較治療前顯著增加,同組治療前后差異具有統(tǒng)計學意義(P<0.05);治療后治療組這些觀察指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P<0.05)。結(jié)論 硫辛酸聯(lián)合精蛋白生物合成人胰島素注射液治療2型糖尿病具有較好的臨床療效,可減少患者注射胰島素的劑量,能夠更好地控制空腹血糖和餐后2 h血糖,提高患者的生活質(zhì)量,具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection in treatment of type 2 diabetes.Methods Patients (300 cases) with type 2 diabetes in Longbai Community Health Service Center of Minhang District in Shanghai from August 2012 to December 2015 were randomly divided into control and treatment groups, and each group had 150 cases. The patients in the control group were scadministered with Isophane Protamine Biosynthetic Human Insulin Injection, 0.4 U/kg for the first time, twice daily, before breakfast and dinner. The dosage was adjusted according to the treatment status of patients. The patients in two groups were treated for 1 month. The dosages of insulin in two groups were observed, and the changes of FBG, 2 h PBG, HbA1c, and scores of quality life in two groups before and after treatment were compared.Results After treatment, the dosage of insulin in treatment group before breakfast, dinner and throughout the day were significantly lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, FBG, 2 h PBG, and HbA1c in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of stress evaluation, social relations, nutritional status, and exercising state were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection has clinical curative effect in treatment of type 2 diabetes, and can reduce the dosage of insulin injection, and can better control FBG and 2 h PBG, also can improve the life quality of patients, which has a certain clinical application value.