目的 研究阿托伐他汀鈣片聯(lián)合阿魏酸哌嗪片治療糖尿病腎病的臨床效果。方法 將漢中市中心醫(yī)院2012年11月-2015年1月收治的糖尿病腎病患者80例,隨機(jī)分為對照組和治療組,每組各40例。對照組在基礎(chǔ)治療的基礎(chǔ)上給予阿魏酸哌嗪片,2片/次,2次/d;治療組在對照組的基礎(chǔ)上口服阿托伐他汀鈣片20 mg/d,1次/d,兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組治療前后腎功能指標(biāo)24 h尿蛋白定量、肌酐和尿素,三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、總膽固醇(TC)的變化。結(jié)果 治療后,對照組和治療組的總有效率分別為70.0%、90.0%,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者的腎功能指標(biāo)24 h尿蛋白定量、尿素、肌酐均較治療前有所改善,且差異有統(tǒng)計學(xué)意義(P<0.05);且治療組治療后腎功能指標(biāo)的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05);兩組患者的血脂水平TG、LDL、TC均較治療前顯著降低,HDL顯著升高,且差異有統(tǒng)計學(xué)差異(P<0.05);且治療組治療后血脂水平的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 阿托伐他汀鈣片聯(lián)合阿魏酸哌嗪片治療糖尿病腎病具有較好的臨床效果,能改善腎功能和血脂,且安全性較高,具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy.MethodsPatients (80 cases) with diabetic nephropathy in Hanzhong Central Hospital from November 2012 to January 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were po administered with Piperazine Ferulate Tablets on the basis of basic treatment, 2 tablets/time, twice daily. The patients in the treatment group were po administered with Atorvastatin Calcium Tablets on the basis of the control group, 20 mg/d, once daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of renal function indexes 24 h urine protein, creatinine, and urea, triacylglycerol (TG), low density lipoproteins (LDL), high density lipoprotein (HDL), and total cholesterol (TC) in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 70.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, renal function indexes 24 h urine protein, creatinine, and urea in two groups were significantly improved, and the difference was statistically significant in the same group (P < 0.05). And those renal function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, lipid levels TG, LDL, and TC in two groups were significantly decreased, and HDL were increased with significant difference (P < 0.05). And those lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets has clinical curative effect in treatment of diabetic nephropathy, and can improve the renal function indexes and lipid levels with high safety, which has a certain clinical application value.