目的 探討血栓通注射液聯(lián)合依帕司他和甲鈷胺注射液治療糖尿病周圍神經(jīng)病變的臨床療效。方法 選取2013年4月-2015年8月在海南省萬(wàn)寧市人民醫(yī)院接受治療的糖尿病周圍神經(jīng)病變患者144例,隨機(jī)分為對(duì)照組(70例)和治療組(74例)。對(duì)照組口服依帕司他片,50 mg/次,3次/d;同時(shí)靜脈滴注甲鈷胺注射液,0.5 mg加入生理鹽水200 mL,1次/d,3次/周。治療組在對(duì)照組治療基礎(chǔ)上靜脈滴注血栓通注射液,2 mL溶于生理鹽水250 mL,1次/d。兩組均連續(xù)治療8周。觀察兩組的臨床療效,同時(shí)比較兩組患者治療前后正中神經(jīng)、腓神經(jīng)的運(yùn)動(dòng)神經(jīng)和感覺(jué)神經(jīng)傳導(dǎo)速度的變化情況。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為81.43%、90.54%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者正中神經(jīng)、腓神經(jīng)的運(yùn)動(dòng)神經(jīng)和感覺(jué)神經(jīng)傳導(dǎo)速度均較治療前有明顯增加,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 血栓通注射液聯(lián)合依帕司他和甲鈷胺注射液治療糖尿病周圍神經(jīng)病變具有較好的臨床療效,能明顯改善患者神經(jīng)傳導(dǎo)速度,且在治療過(guò)程中未發(fā)現(xiàn)嚴(yán)重的不良反應(yīng),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Xueshuantong Injection combined with epalrestat and Mecobalamin Injection in treatment of diabetic peripheral neuropathy.Methods Patients (144 cases) with diabetic peripheral neuropathy in Wanning People's Hospital of Hainan Province from April 2013 to August 2015 were randomly divided into control (n=70) and treatment (n=74) groups. The patients in the control group were poadministered with Epalrestat Tablets, 50 mg/time, three times daily, and they were iv administered with Mecobalamin Injection, 0.5 mg added into normal saline 200 mL, once daily, three times weekly. The patients in the treatment group were ivadministered with Xueshuantong Injection on the basis of the control group, 2mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 8 week. After treatment, the efficacy was evaluated, and the conduction velocity of movement and sensory nerve of median nerve and peroneal nerve in two groups before and after treatment were compared.Results After treatment, the efficacies in the control and treatment groups were 81.43% and 90.54%, respectively, and there were differences between two groups (P < 0.05). After treatment, the conduction velocity of movement and sensory nerve of median nerve and peroneal nerve in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Xueshuantong Injection combined with epalrestat and Mecobalamin Injection has clinical curative effect in treatment of diabetic peripheral neuropathy, and can significantly improve nerve conduction velocity, and there was no serious adverse reactions in the process of treatment, which has a certain clinical application value.