目的 探討寧泌泰膠囊聯(lián)合頭孢曲松鈉治療急性腎盂腎炎的臨床療效。方法 選取2012年12月-2015年9月都江堰市中醫(yī)醫(yī)院收治的急性腎盂腎炎的患者234例,隨機(jī)分為對(duì)照組(114例)和治療組(120例)。對(duì)照組患者靜脈滴注注射用頭孢曲松鈉,2 g加入到0.9%氯化鈉溶液250 mL中,1次/d。治療組在對(duì)照組基礎(chǔ)上口服寧泌泰膠囊,4粒/次,3次/d。兩組患者均持續(xù)治療2周。觀察兩組臨床療效,同時(shí)比較兩組尿路刺激征及發(fā)熱等臨床癥狀消失時(shí)間。結(jié)果 治療后,對(duì)照組和治療組總有效率分別為88.6%、91.7%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組患者尿路刺激征、腰酸痛及發(fā)熱的消失時(shí)間明顯短于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者尿紅細(xì)胞和白細(xì)胞計(jì)數(shù)均顯著下降,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療后,治療組這些觀察指標(biāo)改善程度顯著優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 寧泌泰膠囊聯(lián)合頭孢曲松鈉治療急性腎盂腎炎療效顯著,能夠明顯改善患者的尿痛、尿頻等尿路刺激征及腰酸痛等臨床癥狀,具有一定的臨床推廣應(yīng)用價(jià)值。

ObjectiveTo explore the clinical effect of Ningmitai Capsules combined ceftriaxone sodium in treatment of acute pyelonephritis.Methods Patients (234 cases) with acute pyelonephritis in Dujiangyan Traditional Chinese Medicine Hospital from December 2012 to September 2015 were randomly divided into control (n=114) and treatment (n=120) groups. Patients in the control group were iv administered with Ceftriaxone Sodium for injection, 2 g added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Ningmitai Capsules on the basis of control group, 4 grains/time, three times daily. The patients in two groups were treated for 2 weeks. After treatment, the efficacies were evaluated, and the disappeared times of clinical symptoms such as urinary irritation symptoms and fever was compared.Results After treatment, the efficacies in the control and treatment groups were 88.6% and 91.7%, respectively, and there was difference between groups (P < 0.05). After treatment, the disappeared times of urinary irritation symptoms, backache, and fever in the treatment group were shorter than those in the control group, and there were differences in two groups (P < 0.05). After treatment, urine red blood cell and white blood cell count in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05).Conclusion Ningmitai Capsules combined ceftriaxone sodium has clinical curative effect in treatment of acute pyelonephritis, can significantly improve clinical symptoms such as urinary frequency, urine pain, which has a certain clinical application value.