目的 探討乳酸左氧氟沙星片聯(lián)合三聯(lián)療法治療幽門螺旋桿菌相關(guān)性胃潰瘍的療效。方法 選取2014年6月-2015年6月遼寧省人民醫(yī)院收治的胃潰瘍患者134例,隨機分為對照組和治療組,每組各67例。對照組采用三聯(lián)療法,治療組在對照組的基礎上第6天起口服乳酸左氧氟沙星片200 mg,1次/d。兩組共治療10 d。觀察兩組的幽門螺旋桿菌根除率和臨床療效,比較治療前后兩組血清炎癥因子水平和不良反應發(fā)生率。結(jié)果 治療后,治療組的幽門螺旋桿菌根除率為83.6%,顯著高于對照組的52.2%,對照組和治療組的總有效率分別為79.1%、94.0%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組患者白細胞介素-6(IL-6)、白細胞介素-17(IL-17)水平均較治療前顯著降低,干擾素-γ(IFN-γ)水平顯著升高,同組治療前后差異具有統(tǒng)計學意義(P<0.05);且治療組這些觀察指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P<0.05)。兩組不良反應發(fā)生率比較無統(tǒng)計學意義。結(jié)論 乳酸左氧氟沙星片聯(lián)合三聯(lián)療法治療幽門螺旋桿菌相關(guān)性胃潰瘍具有較好的療效,優(yōu)于單獨應用三聯(lián)療法,能提高總有效率,降低炎癥反應,安全有效,值得在臨床中推廣使用。

Objective To study the efficacy of Levofloxacin Lactate Tablets combined with triple therapy in treatment of Helicobacter pylori associated gastric ulcer.Methods Patients (134 cases) with H. pylori associated gastric ulcer in The People's Hospital of Liaoning Province from June 2014 to Jun 2015 were randomly divided into control (n= 67 ) and treatment (n= 67 ) groups. Patients in the control group were treated with triple therapy, and the patients in the treatment group were poadministered with Levofloxacin Lactate Tablets from 6th day on the basis of the control group, 200 mg/time, once daily. The patients in two groups were treated for 10 d. After treatment, the efficacy and H.pylori eradication rate were evaluated, and inflammatory factors in serum and incidence rate of adverse reaction in two groups were compared.Results After treatment, H. pylori eradication rate in the treatment group (83.6%) was higher than that (52.2%) of the control group, and the efficacies in the control and treatment groups were 79.1% and 94.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, levels of IL-6 and IL-17 in serum in two groups were significantly decreased, but that of IFN-γ were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). There was no difference of incidence rate of adverse reaction between two groups.Conclusions Levofloxacin Lactate Tablets combined with triple therapy has clinical curative effect in treatment ofH. pylori associated gastric ulcer, has better efficacy than the single triple therapy, and can significantly reduce the inflammatory reaction with less increase in adverse reactions, which has a certain clinical application value.