目的 對(duì)2009-2015年涼山州第二人民醫(yī)院鮑曼不動(dòng)桿菌的耐藥性與抗菌藥物用量的相關(guān)性進(jìn)行分析,促進(jìn)臨床合理用藥。方法 統(tǒng)計(jì)2009-2015年涼山州第二人民醫(yī)院檢驗(yàn)科鮑曼不動(dòng)桿菌的分布及耐藥性和抗菌藥物的使用情況,并對(duì)鮑曼不動(dòng)桿菌的耐藥性與抗菌藥物用量的相關(guān)性進(jìn)行統(tǒng)計(jì)分析。結(jié)果 共分離出鮑曼不動(dòng)桿菌2 719株,主要來源為痰液(75.62%),分離株數(shù)逐年增加。鮑曼不動(dòng)桿菌對(duì)各類抗菌藥物的耐藥率均呈上升趨勢(shì),對(duì)左氧氟沙星耐藥率的上升程度最大。對(duì)哌拉西林他唑巴坦、左氧氟沙星、替卡西林、頭孢他啶、頭孢吡肟的耐藥率均接近50%。鮑曼不動(dòng)桿菌對(duì)哌拉西林他唑巴坦、頭孢他啶、頭孢吡肟、左氧氟沙星和米諾環(huán)素的耐藥率與左氧氟沙星的使用強(qiáng)度呈顯著的正相關(guān)性。結(jié)論 合理使用抗菌藥物對(duì)于降低鮑曼不動(dòng)桿菌的耐藥性具有重要意義,應(yīng)根據(jù)藥物半衰期和藥敏試驗(yàn)制定恰當(dāng)?shù)慕o藥方案。

Objective To analyze the correlation between drug resistance of Acinetobacter baumanniiand dose of antibiotics in The Second People's Hospital of Liangshan Prefecture from 2009 to 2015, and to promote rational drug use in clinic.Methods The distribution and drug resistance of A.baumannii, and the usage of antibiotics in Department of Pharmacy in The Second People's Hospital of Liangshan Prefecture from 2009 to 2015. The correlation between drug resistance of A.baumannii and dose of antibiotics were analyzed.Results Total 2 719 strains of A.baumannii were isolated, and the pathogenic bacteria (75.62%) was isolated mainly from sputum samples. The isolated strains of A.baumannii increased year by year. The drug resistance rate of A.baumanniiagainst various kinds of antibacterial drugs was on the rise, and the drug resistance rate against levofloxacin increased the most. The drug resistance rate of A.baumanniiagainst piperacillin/tazobactam, levofloxacin, ticarcillin, ceftazidime, and cefepime were almost 50%. The resistance rates of A.baumannii against piperacillin/tazobactam, ceftazidime, cefepime, levofloxacin, and minocyline had significantly positive correlation with use density of levofloxacin.Conclusion It is of great significance to rational use antimicrobial drugs to reduce the drug resistance rate of A.baumannii. The appropriate dosage regimen should be made based on the half-life of drugs and drug sensitivity test.