目的 運(yùn)用Meta分析方法評(píng)價(jià)鼠神經(jīng)生長(zhǎng)因子治療突發(fā)性耳聾的療效。方法 計(jì)算機(jī)檢索Pubmed、Embase、中國(guó)學(xué)術(shù)期刊(網(wǎng)絡(luò)版)、萬(wàn)方數(shù)字化期刊全文庫(kù),對(duì)納入的隨機(jī)對(duì)照試驗(yàn)文獻(xiàn)進(jìn)行質(zhì)量評(píng)價(jià),并采用Rev Man 5.3軟件進(jìn)行Meta分析。結(jié)局指標(biāo)為總有效率。結(jié)果 共納入10篇隨機(jī)對(duì)照試驗(yàn),共1 093例患者。Meta分析結(jié)果顯示,鼠神經(jīng)生長(zhǎng)因子治療突發(fā)性耳聾的總有效率高于對(duì)照組[OR＝3.21,95%CI(2.31,4.44),P<0.01]。結(jié)論 鼠神經(jīng)生長(zhǎng)因子治療突發(fā)性耳聾具有較好的療效,但仍需開(kāi)展高質(zhì)量的藥物臨床試驗(yàn)。

Objective To evaluate the efficacy of mouse nerve growth factor in treatment of sudden deafness by Meta analysis.Methods By searching Pubmed, Embase, Chinese Academic Journal (CD), and Wanfang Database, the quality assessment of qualified randomly control trials was evaluated. Meta analysis was carried out by Rev Man 5.3 software. The outcomes included the clinical effects.Results A total of 10 studies were included, involving 1 093 patients. Meta analysis showed that the total effective rate of mouse nerve growth factor in treatment of sudden deafness was higher than that in control group [OR = 3.21, 95%CI (2.31, 4.44), P < 0.01].ConclusionMouse nerve growth factor could improve the clinical efficacy of sudden deafness, but it is necessary to carry out high quality of drug clinical trials.