目的 探討宮血寧膠囊聯(lián)合醋酸甲羥孕酮和戊酸雌二醇治療青春期功能失調(diào)性子宮出血的臨床療效。方法 選取2014年1月—2015年1月在海南省第三人民醫(yī)院接受治療的青春期功能失調(diào)性子宮出血患者76例，隨機(jī)分為對照組和治療組，每組各38例。所有患者均給予必要的心理干預(yù)。對照組口服醋酸甲羥孕酮片，8 mg/d，止血3 d后開始減量，每3天減量1/3，維持量為1 mg/d；同時口服戊酸雌二醇片，4～6 mg/次，3次/d。治療組在對照組基礎(chǔ)上口服宮血寧膠囊，2粒/次，3次/d。兩組患者均連續(xù)治療21 d。觀察兩組患者的臨床療效，同時比較治療前后兩組患者止血時間、性激素水平和WHOQOL-BREF評分的變化情況。結(jié)果 治療后，對照組和治療組總有效率分別為84.21%、97.37%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組的有效控制出血時間和完全止血時間明顯短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者促卵泡激素（FSH）、黃體生成素（LH）、雌二醇（E2）水平均明顯降低（P<0.05）；且治療組上述性激素指標(biāo)水平降低更顯著（P<0.05）。治療后，兩組患者生理健康評分、心理狀態(tài)評分、社會關(guān)系評分、周圍環(huán)境評分和總分均較同組治療前升高（P<0.05）；治療組上述各項WHOQOL-BREF評分升高的更明顯（P<0.05）。結(jié)論 宮血寧膠囊聯(lián)合醋酸甲羥孕酮和戊酸雌二醇治療青春期功能失調(diào)性子宮出血療效確切，可有效提高患者生活質(zhì)量，具有一定的臨床應(yīng)用推廣價值。

Objective To study the clinical effect of Gongxuening Capsules combined with medroxyprogesterone acetate and estradiol valerate in treatment of adolescent dysfunctional uterine bleeding. Methods Patients (76 cases) with adolescent dysfunctional uterine bleeding in the Third People's Hospital of Hainan Province from January 2014 to January 2015 were divided into control and treatment groups, and each group had 38 cases. All patients were given necessary psychological interventions. The patients in the control group was po administered with Medroxyprogesterone Acetate Tablets, 8 mg/d, the dosage was reduced by 1/3 every 3 d after hemostasis for 3 d, and maintenance dose was 1 mg/d; And they were po administered with Estradiol Valerate Tablets, 4~6 mg/time, three times daily. The patients in the treatment group were po administered with Gongxuening Capsules, 2 grains/time, three times daily. The patients in two groups were treated for 21 d. The clinical effect in two groups were observed, and the changes of haemostatic time, sex hormone levels, and WHOQOL-BREF scores were compared. Results After treatment, the clinical effect in the control and treatment groups were 84.21% and 97.37%, respectively, and there was difference between two groups (P<0.05). After treatment, the effective control bleeding time and completely haemostatic time in treatment group were shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, FSH, LH, and E2 in two groups were obviously decreased (P<0.05); And the decreasing degree of those sex hormone levels in treatment group was more obvious (P<0.05). After treatment, scores of physical health, psychological state, social relations, environmental, and total score in two groups were significantly increased (P<0.05). The improved degree of those WHOQOL-BREF scores in the treatment group was more significant (P<0.05). Conclusion Gongxuening Capsules combined with medroxyprogesterone acetate and estradiol valerate in treatment of adolescent dysfunctional uterine bleeding has a reliable clinical effect, and can effectively improve the quality of life, which has a certain clinical application value.