目的 探討葛根素注射液聯(lián)合左西孟旦治療慢性充血性心力衰竭臨床療效。方法 選取2013年2月-2014年8月井陘縣醫(yī)院收治的充血性心力衰竭患者98例，隨機分成對照組和治療組，每組各49例。對照組iv左西孟旦注射液，首次劑量12 μg/kg，5～10 min完成，之后調整為0.5 μg/（kg·min）進行維持治療，1次/d。治療組在對照組基礎上靜脈滴注葛根素注射液，500 mg加入5%葡萄糖溶液250 mL中，1次/d。兩組患者均治療20 d。觀察兩組的臨床療效，比較兩組的臨床癥狀和心臟功能。結果 治療后，對照組和治療組的總有效率分別為77.55%、83.67%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組患者中心率（HR）減緩、呼吸困難好轉和啰音消失的比例明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者心排血量（CO）和左心室射血分數(shù)（LVEF）均升高，而左心室舒張末期的壓力（LVEDP）下降，同組治療前后差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的改善程度優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 葛根素注射液聯(lián)合左西孟旦治療慢性充血性心力衰竭具有較好的臨床療效，能緩解臨床癥狀，改善心臟功能，安全性較好，具有一定的臨床推廣應用價值。

Objective To observe the clinical effect of Puerarin Injection combined with levosimendan in treatment of chronic congestive heart failure. Methods Patients (98 cases) with chronic congestive heart failure in Jingxing County Hospital from Februay 2013 to August 2015 were randomly divided into the control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Levosimendan Injection, the first dosage was 12 μg/kg, 5-10 min to finish, and the dosage was 0.5μg/(kg·min), once daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 500 mg added to 5% glucose solution 250 mL, once daily. After treatment, the clinical efficacies were evaluated, and clinical symptom, and heart function in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.55% and 83.6%, respectively, and there was difference between two groups (P<0.05). After treatment, the proportion of HR slow, dyspnea improved, and rales disappeared in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P<0.05). After treatment, CO, LVEF, and LVEDP in two groups were decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Puerarin Injection combined with levosimendan has the curative effect in treatment of chronic congestive heart failure, and can relieve clinical symptom, improve heart function, with good safety, which has a certain clinical application value.