目的 探討丹參川芎嗪注射液聯(lián)合低分子肝素鈣注射液治療急性腦梗死的臨床療效。方法 選取唐山市第九醫(yī)院2013年12月-2016年1月收治的80例急性腦梗死患者作為研究對(duì)象，按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各40例。對(duì)照組皮下注射低分子肝素鈣注射液5 000 U，2次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注丹參川芎嗪注射液，10 mL加入5%葡萄糖溶液250 mL，1次/d。兩組患者均治療28 d。觀察兩組患者的臨床療效，比較兩組治療前后血液流變學(xué)指標(biāo)和美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為75.00%、95.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者全血低切黏度、全血高切黏度、纖維蛋白、血漿黏度均明顯降低，同組治療前后差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組這些觀察指標(biāo)的降低程度優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療7、14、28 d后，兩組患者NIHSS評(píng)分均明顯降低，同組治療前后差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療7、14、28 d后，治療組NIHSS評(píng)分均低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 丹參川芎嗪注射液聯(lián)合低分子肝素鈣注射液治療急性腦梗死具有較好的臨床療效，可明顯改善血液流變學(xué)指標(biāo)，促進(jìn)神經(jīng)功能恢復(fù)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Low Molecular Weight Heparins Calcium Injection in treatment of acute cerebral infarction. Methods Patients (80 cases) with acute traumatic cerebral infarction in Tangshan Ninth Hospital from December 2013 to February 2016 were enrolled in this study, and were divided into control group and treatment group according to random number table, and each group had 40 cases. Patients in the control group were sc administered with Low Molecular Weight Heparins Calcium Injection 5 000 U, twice daily; Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into 5% glucose solution 250 mL, once daily. The patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and hemodynamics indexes and NIHSS score in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.00% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, low blood viscosity, whole blood viscosity, plasma viscosity, and fibrinogen of two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment for 7, 14 and 28 d, NIHSS scores of two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, NIHSS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Low Molecular Weight Heparins Calcium Injection has a good clinical efficacy in treatment of acute cerebral infarction, can improve hemorheology indexes, and promote the recovery of neurological function, which has a certain clinical application value.

河北省科學(xué)技術(shù)廳資助項(xiàng)目（20140673）