目的 探討安胃瘍膠囊聯(lián)合四聯(lián)療法治療難治性消化性潰瘍的臨床療效。方法 選取2015年3月-2016年3月在重慶市開(kāi)縣人民醫(yī)院接受治療的難治性消化性潰瘍患者94例，隨機(jī)分為對(duì)照組和治療組，每組各47例。對(duì)照組給予四聯(lián)療法治療，治療組在對(duì)照組的基礎(chǔ)上口服安胃瘍膠囊，0.4 g/次，4次/d。兩組患者均連續(xù)用藥4周。觀察兩組患者臨床療效，同時(shí)比較兩組治療前后血清一氧化氮（NO）、內(nèi)皮素（ET）、血管內(nèi)皮生長(zhǎng)因子（VEGF）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TGF-α）水平，幽門螺桿菌（HP）清除率的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為85.11%、97.87%，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清ET、IL-6、TGF-α水平均顯著降低，而NO、VEGF水平顯著升高，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)改善程度優(yōu)于對(duì)照組，兩組比較差異有具統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組HP根除率分別為80.85%、95.74%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 安胃瘍膠囊聯(lián)合四聯(lián)療法治療難治性消化性潰瘍具有顯著的臨床療效，可明顯改善血清細(xì)胞因子水平，提高HP根除率，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Anweiyang Capsules combined with quadruple therapy in treatment of refractory peptic ulcer. Methods Patients (94 cases) with refractory peptic ulcer in the People's Hospital of Kaixian County in Chongqing from March 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 47 cases. The patients in the control group were given quadruple therapy. The patients in the treatment group were po administered with Anweiyang Capsules on the basis of the control group, 0.4 g/time, four times daily. Each groups was treated for 4 weeks. After treatment, the clinical effect was evaluated, the changes of serum NO, ET, VEGF, IL-6, TGF-α levels, and HP eradication rate in two groups were compared. Results After treatment, the clinical effect in the control and treatment groups were 85.11% and 97.87%, respectively, and there were differences between two groups (P<0.05). After treatment, serum ET, IL-6, and TGF-α level in two groups were significantly decreased, NO and VEGF levels were increased, the difference was statistically significant in the same group (P<0.05). The observation indexes in treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The HP eradication rates in the control and treatment groups were 80.85% and 95.74%, respectively, and the difference was statistically significant between two groups (P<0.05). Conclusion Anweiyang Capsules combined with quadruple therapy has the good clinical effect in treatment of refractory peptic ulcer, can significantly improve the serum cytokine levels and the HP eradication rate, which has a certain clinical application value.