目的 設計和合成苯酰胺類c-Met激酶抑制劑，并測定其體外抗腫瘤活性。方法 以4-氯-6,7二甲氧基喹啉、6-氯-7-氮雜嘌呤和4-氯-7-氮雜吲哚為起始物，經(jīng)取代、還原和縮合反應制備目標化合物3a～5c，并采用噻唑藍法（MTT）測定目標化合物對GTL-16細胞的抑制作用。結果 合成了9個化合物，其結構經(jīng)MS、¹H-NMR和¹³C-NMR確證?；衔?b>3a～5c對GTL-16細胞均呈現(xiàn)不同程度的抑制作用，其中化合物3c對GTL-16細胞的IC₅₀達到411 nmol/L。結論 苯酰胺類化合物具有抑制GTL-16細胞活性的作用，值得進一步深入研究。

Objective To design and synthesize benzamide compounds c-Met inhibitors, and study their anti-tumor activities in vitro. Methods 6,7-Dimethoxy-4-chloroquinoline, 6-chloro-7-deazapurinepurine, and 4-chloro-7-azaindole were used as starting material to synthesize the target compounds 3a-5c by substitution, reduction and condensation reactions. The antitumor activities of the compounds against GTL-16 cells were investigated by methyl thiazolyl tetrazoliym (MTT) assay. Results Nine novel benzamide compounds were synthesized. The structures were characterized by MS, ¹H-NMR, and ¹³C-NMR techniques. All of the compounds had different extents potency of antitumor activities against GTL-16 cells. Especially the IC₅₀ value of the compound 3c was 411 nmol/L. Conclusion Benzamide compounds have good antitumor activities against GTL-16 cells, which could be a valuable candidate for further development.