目的 探討紅花黃色素聯(lián)合阿托伐他汀治療不穩(wěn)定型心絞痛的臨床療效。方法 選取2015年3月-2016年2月瀘州市人民醫(yī)院收治的不穩(wěn)定型心絞痛患者86例，隨機(jī)分為對(duì)照組和治療組，每組各43例。對(duì)照組口服阿托伐他汀鈣片，20 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注注射用紅花黃色素，100 mg加入到250 mL生理鹽水中，1次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效和心電圖療效，比較兩組臨床癥狀、炎性指標(biāo)及血脂指標(biāo)的情況。結(jié)果 治療后，對(duì)照組和治療組的臨床療效的總有效率分別為76.74%、95.35%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組的心電圖療效的總有效率分別為39.53%、65.11%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組心絞痛發(fā)作頻率、持續(xù)時(shí)間及心絞痛疼痛程度顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的降低程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組hs-CRP、TNF-α及IL-6顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的降低程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組TC、TG及LDL-C顯著降低，而HDL-C顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 紅花黃色素聯(lián)合阿托伐他汀治療不穩(wěn)定型心絞痛具有較好的臨床療效，可改善臨床癥狀，減輕炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of safflower yellow combined with atorvastatin in treatment of unstable angina pectoris. Methods Patients (86 cases) with unstable angina pectoris in Luzhou People's Hospital from March 2015 to February 2016 were randomly divided into the control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were iv administered with Safflower Yellow for injection on the basis of the control group, 100 mg added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical and electrocardiographic efficacies were evaluated, and clinical symptoms, inflammatory indexes, and blood lipid indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.74% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the electrocardiographic efficacies in the control and treatment groups were 39.53% and 65.11%, respectively, and there was difference between two groups (P<0.05). After treatment, attack frequency, duration, and pain degree of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, hs-CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, TC, TG, and LDL-C in two groups were significantly decreased, but HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Safflower yellow combined with atorvastatin has clinical curative effect in treatment of unstable angina pectoris, and improve clinical symptoms, reduce inflammatory reactions, which has a certain clinical application value.