目的 探討骨愈靈膠囊聯(lián)合注射用骨肽治療骨質(zhì)疏松癥的臨床療效。方法 選取2013年5月-2016年2月在榆林市第一醫(yī)院骨科接受治療的骨質(zhì)疏松癥患者110例，按治療方法的不同分為對(duì)照組和治療組，每組各55例。對(duì)照組患者靜脈滴注注射用骨肽，60 mg加入200 mL生理鹽水，1次/d。治療組在對(duì)照組基礎(chǔ)上口服骨愈靈膠囊，5粒/次，3次/d。兩組患者均治療2個(gè)月。觀察兩組患者的臨床療效，比較兩組患者治療前后骨代謝指標(biāo)以及骨密度（BMD）、骨鈣素（BGP）、骨形態(tài)發(fā)生蛋白-2（BMP-2）變化情況。結(jié)果 治療后，對(duì)照組、治療組總有效率分別為81.82%、94.55%，兩組患者總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血磷（S-P）、抗酒石酸酸性磷酸酶-5b（TRAP-5b）明顯降低，血鈣（S-Ca）、骨堿性磷酸酶（B-ALP）顯著升高，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組上述骨代謝指標(biāo)的改善程度優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者L_2～4 BMD、股骨頸BMD、BGP、BMP-2均明顯增加，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組BMD、BGP和BMP-2的增加程度優(yōu)于對(duì)照組（P<0.05）。結(jié)論 骨愈靈膠囊聯(lián)合注射用骨肽治療骨質(zhì)疏松癥療效顯著，可改善患者BMD、骨代謝和骨轉(zhuǎn)換狀態(tài)，減少骨量流失，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Guyuling Capsules combined with Ossotide for injection in treatment of osteoporosis. Methods Patients (110 cases) with osteoporosis in Department of Orthopaedics of The First Hospital of Yulin from May 2013 to February 2016 were divided into control and treatment groups according to different treatments, and each group had 55 cases. The patients in the control group were iv administered with Ossotide for injection, 60 mg Ossotide for injection added into normal saline 200 mL, once daily. The patients in the treatment group were po administered with Guyuling Capsules on the basis of the control group, 5 grains/time, three times daily. The patients in two groups were treated for 2 months. After treatment, the efficacies were evaluated, and the changes of bone metabolism indexes, BMD, BGP, and BMP-2 in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 81.82% and 94.55%, respectively, and there were differences between two groups (P<0.05). After treatment, S-P and TRAP-5b in two groups were significantly decreased, S-Ca and B-ALP were increased, and the difference was statistically significant in the same group (P<0.05). And these bone metabolism indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, L_2~4 BMD, femoral neck BMD, BGP, and BMP-2 in the two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the increase degree of BMD, BGP and BMP-2 in treatment group was higher than those in the control group (P<0.05). Conclusion Guyuling Capsules combined with Ossotide for injection has obvious clinical curative effect in treatment of osteoporosis, and can improve BMD, bone metabolism and bone turnover with the loss of bone mass reducing, which has a certain clinical application value.