目的 探討滑膜炎顆粒聯(lián)合玻璃酸鈉注射液治療創(chuàng)傷性膝關(guān)節(jié)滑膜炎的臨床療效。方法 選取2015年5月-2016年4月在漢中市中心醫(yī)院接受治療的創(chuàng)傷性膝關(guān)節(jié)滑膜炎患者80例，根據(jù)治療方案的差別分為對(duì)照組和治療組，每組各40例。對(duì)照組患者關(guān)節(jié)腔注射玻璃酸鈉注射液，2 mL/次，1次/周。治療組在對(duì)照組的基礎(chǔ)上口服滑膜炎顆粒，1袋/次，3次/d。兩組患者均連續(xù)治療5周。觀察兩組的臨床療效，同時(shí)比較兩組治療前后VAS評(píng)分、HSS評(píng)分、癥狀體征積分、腫瘤壞死因子-α（TNF-α）、白介素-1（IL-1）和白介素-6（IL-6）水平的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為80.00%、95.00%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者VAS評(píng)分降低，而HSS評(píng)分升高，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組VAS和HSS評(píng)分的改善程度優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者腫脹評(píng)分、疼痛評(píng)分、活動(dòng)度評(píng)分和臨床癥狀積分均較治療前顯著降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組上述癥狀體征積分降低更明顯，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組TNF-α、IL-1、和IL-6水平顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組的降低程度優(yōu)于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 滑膜炎顆粒聯(lián)合玻璃酸鈉治療創(chuàng)傷性膝關(guān)節(jié)滑膜炎的效果顯著，可明顯改善患者臨床癥狀，降低炎性因子水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To evaluate the clinical efficacies of Huamoyan Granules combined with sodium hyaluronate in treatment of traumatic synovitis of knee joint. Methods Patients (80 cases) with traumatic synovitis of knee joint in Hanzhong Central Hospital from May 2015 to April 2016 were divided into control and treatment groups based on different treatments, and each group had 40 cases. The patients in the control group were intra-articular injection administered with Sodium Hyaluronate Injection, 2 mL/time, once a week. The patients in the treatment group were po administered with Huamoyan Granules on the basis of the control group, 1 bag/time, three times daily. The patients in two groups were treated for 5 weeks. After treatment, clinical efficacies were evaluated, and VAS scores, HSS scores, symptom and sign scores, TNF-α, IL-1, and IL-6 in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, VAS scores in two groups were decreased, but HSS scores were increased, and the difference was statistically significant in the same group (P<0.05). And the improvement of VAS and HSS scores in the treatment group were better than those in the control group, with significant difference between two groups (P<0.05). After treatment, swelling scores, pain scores, activity scores, and symptom and sign scores in two groups were lower than those in the same group before treatment, and there were differences in the same group (P<0.05). And these symptom and sign scores in the treatment group were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, TNF-α, IL-1, and IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of these observational indexes in treatment group was better than those in control group, with significant difference between two groups (P<0.05). Conclusion Huamoyan Granules combined with sodium hyaluronate in treatment of traumatic synovitis of knee joint has a significant clinical efficacy, can obviously improve the clinical symptoms and reduce the expression of inflammatory factor, which has a certain clinical application value.