目的 探討固本益腸片聯(lián)合布拉氏酵母菌散和維生素C治療小兒抗生素相關(guān)性腹瀉的臨床療效。方法 選取2013年5月-2015年5月延安大學(xué)附屬醫(yī)院收治的抗生素相關(guān)性腹瀉患兒120例，隨機(jī)分為對照組和治療組，每組各60例。對照組口服布拉氏酵母菌散，0.25 g/次，患兒≥3歲：2次/d，患兒<3歲：1次/d。且對照組還口服維生素C顆粒，0.5 g/次，1次/d。治療組在對照組的基礎(chǔ)上口服固本益腸片，1.28 g/次，3次/d。兩組患兒均治療2周。觀察兩組的臨床療效及復(fù)發(fā)率，同時比較臨床癥狀、免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）及T細(xì)胞亞群（CD³⁺、CD⁴⁺、CD⁸⁺、CD⁴⁺/CD⁸⁺）的變化。結(jié)果 治療后，對照組和治療組的總有效率分別為73.3%、93.3%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，對照組和治療組的復(fù)發(fā)率分別為18.3%、5.0%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組腹瀉緩解時間、發(fā)熱緩解時間、惡心緩解時間、嘔吐緩解時間及治愈時間較對照組均縮短，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，對照組和治療組IgG、IgA、IgM、CD³⁺、CD⁴⁺、CD⁸⁺及CD⁴⁺/CD⁸⁺均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 固本益腸片聯(lián)合布拉氏酵母菌散和維生素C治療小兒抗生素相關(guān)性腹瀉具有較好的臨床療效，能降低復(fù)發(fā)率，縮短癥狀緩解時間與治療時間，增強(qiáng)患兒免疫功能，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Guben Yichang Tablets combined with Saccharomyces Boulardii Sachets and vitamin C in treatment of antibiotic-associated diarrhea in children. Methods Children (120 cases) with antibiotic-associated diarrhea in Yan'an University Affiliated Hospital from May 2013 to May 2015 were randomly divided into control and treatment groups, and each group had 60 cases. Children in the control group were po administered with Saccharomyces Boulardii Sachets, 0.25 g/time, age ≥3 years:twice daily, age <3 years:once daily. And children in the control group were also po administered with Vitamin C Granules, 0.5 g/time, once daily. Children in the treatment group were po administered with Guben Yichang Tablets on the basis of the control group, 1.28 g/time, three times daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms, IgG, IgA, IgM, and T cell subsets (CD³⁺, CD⁴⁺, CD⁸⁺, and CD⁴⁺/CD⁸⁺) in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.3% and 93.3%, respectively, and there was difference between two groups (P<0.05). After treatment, the recurrence rate in the control and treatment groups were 18.3% and 5.0%, respectively, and there was difference between two groups (P<0.05). After treatment, diarrhea relief time, fever relief time, nausea relief time, vomiting relief time, and cure time in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, IgG, IgA, IgM, CD³⁺, CD⁴⁺, CD⁸⁺, and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guben Yichang Tablets combined with Saccharomyces Boulardii Sachets and vitamin C has clinical curative effect in treatment of antibiotic-associated diarrhea in children, and can reduce recurrence rate, shorten clinical symptoms relief time and cure time, enhance immune function, which has a certain clinical application value.