目的 觀察磷酸奧司他韋顆粒聯(lián)合單磷酸阿糖腺苷治療小兒手足口病的臨床療效。方法 選擇2013年8月-2015年6月在首都兒科研究所附屬兒童醫(yī)院感染科收治的小兒手足口病患者64例。所有患者隨機(jī)分為對照組和治療組，每組各32例。對照組靜脈注射或肌肉注射單磷酸阿糖腺苷治療，5～10 mg/kg加入到0.9%氯化鈉溶液2 mL中，1次/d；治療組在對照組基礎(chǔ)上口服磷酸奧司他韋顆粒，體質(zhì)量≤15 kg：30 mg/次，15 kg < 體質(zhì)量≤23 kg：45 mg/次，23 kg < 體質(zhì)量≤40 kg：60 mg/次，體質(zhì)量>40 kg：75 mg/次，2次/d。兩組患者均連續(xù)治療10 d。觀察兩組的臨床療效，比較兩組患者的發(fā)熱消退時(shí)間、皮疹皰疹消退時(shí)間及痊愈時(shí)間。結(jié)果 治療后，對照組和治療組的總有效率分別為87.5%、96.9%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者的發(fā)熱消退時(shí)間、皮疹皰疹消退時(shí)間及痊愈時(shí)間均顯著短于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 磷酸奧司他韋顆粒聯(lián)合單磷酸阿糖腺苷治療小兒手足口病具有較好的臨床療效，能緩解臨床癥狀，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Oseltamivir Phosphate Granules combined with vidarabine monophosphate in treatment of children with hand foot and mouth disease. Methods Children (64 cases) with hand foot and mouth disease in Department of Infectious Diseases, Children's Hospital Affiliated to Capital Institute of Pediatrics from August 2013 to June 2015 were randomly divided into the control and treatment groups, and each group had 32 cases. Children in the control group were iv or im administered with Vidarabine Monophosphate for injection, 5-10 mg/kg added to normal saline 2 mL, once daily. Children in the treatment group were po administered with Oseltamivir Phosphate Granules on the basis of the control group, body weight ≤15 kg:30 mg/time, 15 kg < body weight≤23 kg:45 mg/time, 23 kg < body weight≤40 kg:60 mg/time, body weight >40 kg:75 mg/time, twice daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and fever subsided time, rash herpes subsided time, and recovery time in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.5% and 96.9%, respectively, and there was difference between two groups (P<0.05). After treatment, fever subsided time, rash herpes subsided time, and recovery time in the treatment group were shorter than those in the control group, with significantly difference between two groups (P<0.05). Conclusion Oseltamivir Phosphate Granules combined with vidarabine monophosphate has clinical curative effect in treatment of children with hand foot and mouth disease, and can relieve clinical symptoms with good safety, which has a certain clinical application value.