目的 探討艾迪注射液聯(lián)合博來霉素治療惡性胸腔積液的臨床療效。方法 選取2014年1月-2015年11月榆林市第一醫(yī)院收治的惡性胸腔積液患者100例，采取隨機(jī)數(shù)字表法分成對照組和治療組，每組各50例。對照組胸腔內(nèi)注入注射用鹽酸博來霉素，60 mg加入到40 mL生理鹽水中，1次/周。治療組在對照組基礎(chǔ)上胸腔內(nèi)注入艾迪注射液，100 mL，1次/周。兩組患者連續(xù)治療4周。觀察兩組的臨床療效，比較兩組患者的生活質(zhì)量和不良反應(yīng)發(fā)生情況。結(jié)果 治療后，對照組和治療組的總有效率分別為62.00%、84.00%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對照組和治療組的生活質(zhì)量改善率分別為52.00%、74.00%，兩組改善率比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組胸痛、發(fā)熱、惡心嘔吐、白細(xì)胞下降的不良反應(yīng)發(fā)生率明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 艾迪注射液聯(lián)合博來霉素治療惡性胸腔積液具有較好的臨床療效，能提高患者生存質(zhì)量，安全性好，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Aidi Injection combined with bleomycin in treatment of malignant pleural effusion. Methods Patients (100 cases) with malignant pleural effusion in the First Hospital of Yulin from January 2014 to November 2015 were randomly divided into control and treatment groups by digital table, and each group had 50 cases. Patients in the control group were ip injected with Bleomycin Hydrochloride for injection, 60 mg added to 40 mL normal saline, once weekly. Patients in the treatment group were ip injected with Aidi Injection (100 mL) on the basis of the control group, once weekly. After treatment, the clinical efficacies were evaluated, and quality of life and safety in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 62.00% and 84.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement of quality of life in the control and treatment groups were 52.00% and 74.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the incidence of chest pain, fever, nausea, and vomiting, and white blood cell declined in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Aidi Injection combined with bleomycin has clinical curative effect in treatment of malignant pleural effusion, and can improve quality of life with good safety, which has a certain clinical application value.