目的 探討甜夢口服液聯(lián)合佐匹克隆治療老年肺心病失眠的臨床療效。方法 選取2013年2月-2015年2月天津市職業(yè)病防治院收治的老年肺心病失眠患者110例，隨機分為對照組（52例）和治療組（58例）。對照組患者口服佐匹克隆片7.5 mg/次，1次/d。治療組在對照組治療基礎上口服甜夢口服液20 mL/次，2次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效，同時比較兩組治療前后匹茲堡睡眠指數(shù)（PSQI）、睡眠總時間、睡眠效率、睡眠潛伏期、快動眼（REM）潛伏期、覺醒次數(shù)、覺醒總時間、pH值、二氧化碳分壓（pCO₂）、氧分壓（pO₂）、的變化。結果 治療后，對照組和治療組的總有效率分別為65.38%、87.93%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者PSQI總分、睡眠潛伏期、REM潛伏期、覺醒次數(shù)、覺醒總時間、pCO₂均顯著降低，睡眠總時間、睡眠效率、pH值、pO₂、SaO₂均顯著升高，同組治療前后差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的改善程度優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。結論 甜夢口服液聯(lián)合佐匹克隆治療老年肺心病失眠具有較好的臨床療效，可改善患者的睡眠質量，降低PSQI評分，具有一定的臨床推廣應用價值。

Objective To observe the clinical curative effect of Tianmeng Oral Solution combined with zopiclone in treatment of senile cor pulmonale insomnia. Methods Patients (110 cases) with senile cor pulmonale insomnia in Tianjin Occupational Disease Prevention and Therapeutic Hospital from February 2013 to February 2015 were randomly divided into control (52 cases) and treatment (58 cases) groupss. The patients in the control group were po administered with Zopiclone Tablets, 7.5 mg/time, once daily. The patients in the treatment group were po administered with Tianmeng Oral Solution on the basis of the control group, 20 mL/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of PSQI scores, total sleep time, sleep efficiency, sleep latency, quick eye movement (REM) incubation period, awakening times, awakening total time, pH, pCO₂, pO₂ in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 65.38% and 87.93%%, respectively, and there were differences between two groups (P<0.05). After treatment, PSQI scores, sleep latency, REM incubation period, awakening times, awakening total time, and pCO₂ were significantly reduced, and total sleep time, sleep efficiency, pH, pO₂, and SaO₂ were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Tianmeng Oral Solution combined with zopiclone has clinical curative effect in treatment of senile cor pulmonale insomnia, and can improve the sleep quality of patients, also can reduce the PSQI scores, which has a certain clinical application value.