目的 研究阿司匹林腸溶片聯(lián)合雌二醇片/雌二醇地屈孕酮片復(fù)合包裝在改善薄型子宮內(nèi)膜的臨床效果。方法 選擇2013年1月-2015年6月在衡水市第二人民醫(yī)院就診的薄型子宮內(nèi)膜患者160例，隨機(jī)分為對(duì)照組和治療組，每組各80例。對(duì)照組口服雌二醇片/雌二醇地屈孕酮片復(fù)合包裝，每28天為1個(gè)周期。前14 d每日口服1片磚紅色片（內(nèi)含雌二醇2mg）；后14 d，每日口服1片黃色片（內(nèi)含雌二醇2 mg和地屈孕酮10 mg）。治療組在對(duì)照組的治療基礎(chǔ)上口服阿司匹林腸溶片，1片/d，1次/d，至當(dāng)月排卵后的第7天停止服藥。兩組均連續(xù)治療3個(gè)周期。觀察兩組治療前后子宮內(nèi)膜的微血管密度（MVD）、子宮內(nèi)膜厚度、整合素β₃、阻力指數(shù)（RI）、搏動(dòng)指數(shù)（PI）、動(dòng)脈血流收縮期峰值（S）和舒張末期的谷值（D）比值（S/D）的變化情況。比較兩組妊娠情況。結(jié)果 治療后，兩組子宮內(nèi)膜MVD和厚度、整合素β₃均較治療前有所增加，兩組RI、PI、S/D均較治療前有所降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組的妊娠率分別為27.50%、53.75%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 阿司匹林腸溶片聯(lián)合雌二醇片/雌二醇地屈孕酮片復(fù)合包裝能夠顯著增加薄型子宮內(nèi)膜患者的子宮內(nèi)膜厚度，改善子宮血流情況，增加妊娠率，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Aspirin Enteric-coated Tablets combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets in improvement of thin endometrium. Methods Patients (160 cases) with thin endometrium in the Second People's Hospital of Hengshui from January 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 80 cases. The patients in the control group were po administered with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets, and every 28 d was as one course. Before 14 d, the patients in the control group were po administered with brick red tablets (containing 2 mg estradiol), one tablet/time, once daily, and after 14 d, they were po administered with yellow tablets (containing 2 mg estradiol and 10 mg progesterone), one tablet/time, once daily. The patients in the treatment group were po administered with Aspirin Enteric-coated Tablets until day 7 after ovulation on the basis of the control group, one tablet/time, once daily. The patients in two groups were treated for three courses. After treatment, the changes of the endometrial MVD, endometrial thickness, integrin β₃, RI, PI, and S/D in two groups before and after treatment were compared. Results After treatment, endometrial MVD, endometrial thickness, and integrin β₃ in two group were significantly increased, and RI, PI, and S/D in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the pregnancy rates in the control and treatment groups were 27.50% and 53.75%, respectively, and there were differences between two groups (P<0.05). Conclusion Aspirin Enteric-coated Tablets combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets can significantly increase the endometrium thickness in patients with endometrial thickness, and can improve uterine blood flow, also can increase the pregnancy rate, which has a certain clinical application value.