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[摘要]
目的 探討甜夢口服液聯(lián)合右佐匹克隆治療腦梗死后失眠癥臨床療效。方法 選取2014年7月-2015年7月在鐵嶺市中心醫(yī)院神經(jīng)內(nèi)科接受治療的腦梗死后失眠癥患者96例,隨機(jī)分為對照組和治療組,每組各48例。對照組患者睡前口服右佐匹克隆片,初始劑量1.5 mg/次,3 d后3 mg/次。治療組在對照組基礎(chǔ)上口服甜夢口服液,20 mL/次,3次/d。兩組患者均治療1個(gè)月。觀察兩組的臨床療效,比較兩組改良愛丁堡-斯堪的那維亞卒中量表(MESSS)評分、匹茲堡睡眠質(zhì)量量表(PSQI)評分和綜合醫(yī)院焦慮抑郁量表(HAD)評分情況。結(jié)果 治療后,對照組和治療組的總有效率分別為83.33%、95.83%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組MESSS評分、PSQI評分和HAD評分均明顯降低,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 甜夢口服液聯(lián)合右佐匹克隆治療腦梗死后失眠癥具有較好的臨床療效,有利于患者神經(jīng)功能恢復(fù),提高患者睡眠質(zhì)量,具有一定的臨床推廣應(yīng)用價(jià)值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Tianmeng Oral Liquid combined with eszopiclone in treatment of post-stroke insomnia. Methods Patients (96 cases) with post-stroke insomnia in Department of Neurology of Tieling Central Hospital from July 2014 to July 2015 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Eszopiclone Tablets before bedtime, the initial dose was 1.5 mg/time, and 3 mg/time after 3 d. Patients in the treatment group were po administered with Tianmeng Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and MESSS score, PSQI score, and HAD score in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 95.83%, respectively, and there was difference between two groups (P<0.05). After treatment, MESSS score, PSQI score, and HAD score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Tianmeng Oral Liquid combined with eszopiclone has clinical curative effect in treatment of post-stroke insomnia, and contribute to the recovery of neurological function, improve the quality of sleep, which has a certain clinical application value.
[中圖分類號(hào)]
[基金項(xiàng)目]