1H-NMR、MS確證了結(jié)構(gòu)。精制收率為16.0%，HPLC面積歸一化法測(cè)得質(zhì)量分?jǐn)?shù)為94%。結(jié)論 制備了硫酸頭孢噻利E型異構(gòu)體，為硫酸頭孢噻利中雜質(zhì)研究提供參考。;Objective To study the synthetic technology of E-isomer of cefoselis sulfate. Methods Aminothiaoximo acid was used as the starting material to synthesize E-isomer of cefoselis sulfate. Results The target compound was synthesized and characterized by 1H-NMR and MS. The purified yield of this synthetic route was 16.0%, and the purity of E-isomer of cefoselis sulfate was 94%. Conclusion E-isomer of cefoselis sulfate is obtained which provides reference for impurity study of cefoselis sulfate."/>

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首頁(yè) > 過(guò)刊瀏覽>2016年第31卷第11期 >2016,31(11):1689-1691. DOI:10.7501/j.issn.1674-5515.2016.11.001
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硫酸頭孢噻利E型異構(gòu)體的合成工藝研究

Synthesis of trans-isomer of cefoselis sulfate

發(fā)布日期：2016-11-29
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    [關(guān)鍵詞]
    [摘要]
    目的 對(duì)硫酸頭孢噻利E型異構(gòu)體的合成工藝進(jìn)行研究。方法 以氨噻肟酸為起始原料，定向合成硫酸頭孢噻利E型異構(gòu)體。結(jié)果 合成了目標(biāo)化合物硫酸頭孢噻利E型異構(gòu)體，并利用1H-NMR、MS確證了結(jié)構(gòu)。精制收率為16.0%，HPLC面積歸一化法測(cè)得質(zhì)量分?jǐn)?shù)為94%。結(jié)論 制備了硫酸頭孢噻利E型異構(gòu)體，為硫酸頭孢噻利中雜質(zhì)研究提供參考。
    [Key word]
    [Abstract]
    Objective To study the synthetic technology of E-isomer of cefoselis sulfate. Methods Aminothiaoximo acid was used as the starting material to synthesize E-isomer of cefoselis sulfate. Results The target compound was synthesized and characterized by 1H-NMR and MS. The purified yield of this synthetic route was 16.0%, and the purity of E-isomer of cefoselis sulfate was 94%. Conclusion E-isomer of cefoselis sulfate is obtained which provides reference for impurity study of cefoselis sulfate.
    [中圖分類(lèi)號(hào)]
    [基金項(xiàng)目]
    天津市科技支撐計(jì)劃重點(diǎn)項(xiàng)目（05YFGZGX03100）