目的 對硫酸頭孢噻利E型異構體的合成工藝進行研究。方法 以氨噻肟酸為起始原料，定向合成硫酸頭孢噻利E型異構體。結果 合成了目標化合物硫酸頭孢噻利E型異構體，并利用¹H-NMR、MS確證了結構。精制收率為16.0%，HPLC面積歸一化法測得質量分數(shù)為94%。結論 制備了硫酸頭孢噻利E型異構體，為硫酸頭孢噻利中雜質研究提供參考。

Objective To study the synthetic technology of E-isomer of cefoselis sulfate. Methods Aminothiaoximo acid was used as the starting material to synthesize E-isomer of cefoselis sulfate. Results The target compound was synthesized and characterized by ¹H-NMR and MS. The purified yield of this synthetic route was 16.0%, and the purity of E-isomer of cefoselis sulfate was 94%. Conclusion E-isomer of cefoselis sulfate is obtained which provides reference for impurity study of cefoselis sulfate.

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