目的 探討普羅布考聯(lián)合阿托伐他汀治療大動脈粥樣硬化性腦梗死臨床療效。方法 選取2013年2月-2015年2月邢臺市第三醫(yī)院收治的大動脈粥樣硬化性腦梗死患者100例，隨機(jī)分為對照組和治療組，每組各50例。對照組睡前口服阿托伐他汀鈣片，20 mg/次，1次/d。治療組在對照組基礎(chǔ)上口服普羅布考片，500 mg/次，2次/d。兩組均治療12周。觀察兩組的臨床療效，比較兩組抗氧化能力、血管內(nèi)皮功能和頸動脈內(nèi)膜中層厚度（IMT）和斑塊面積的情況。結(jié)果 治療后，對照組和治療組的總有效率分別為72.0%、88.0%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組氧化低密度脂蛋白（ox-LDL）和丙二醛（MDA）均顯著下降，而超氧化物歧化酶（SOD）均顯著上升，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組內(nèi)皮素-1（ET-1）均顯著下降，而一氧化氮（NO）和反應(yīng)性充血后血管內(nèi)徑變化率（FMD）均顯著上升，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組IMT和斑塊面積均顯著下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 普羅布考聯(lián)合阿托伐他汀治療大動脈粥樣硬化性腦梗死具有較好的療效，可改善機(jī)體應(yīng)激反應(yīng)和血管內(nèi)皮功能，減少IMT和斑塊面積，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the effect of probucol combined with atorvastatin in treatment of large artery atherosclerotic cerebral infarction. Methods Patients (100 cases) with large artery atherosclerotic cerebral infarction in Xingtai Third Hospital from February 2013 to February 2015 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets before bedtime, 20 mg/time, once daily. Patients in the treatment group were po administered with Probucol Tablets on the basis of the control group, 500 mg/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and antioxidant capacity, vascular endothelial function, IMT, and plaque area in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.0% and 88.0%, respectively, and there was difference between two groups (P<0.05). After treatment, ox-LDL and MDA in two groups were significantly decreased, but the SOD in two groups was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the ET-1 in two groups were significantly decreased, but the NO and FMD in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, IMT and plaque area in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Probucol combined with atorvastatin has clinical curative effect in treatment of large artery atherosclerotic cerebral infarction, and can improve stress response and vascular endothelial function, decrease IMT and plaque area, which has a certain clinical application value.