目的 研究丹參川芎嗪注射液聯(lián)合美托洛爾治療冠心病心絞痛的臨床療效。方法 選擇2013年1月-2015年12月如皋市人民醫(yī)院收治的冠心病心絞痛患者80例，隨機分為對照組和治療組，每組各40例。對照組患者口服酒石酸美托洛爾片，12.5 mg/次，2次/d。治療組在對照組的基礎(chǔ)上靜脈滴注丹參川芎嗪注射液，10 mL加入5%葡萄糖注射液250 mL，1次/d。兩組患者均連續(xù)治療2周。觀察兩組的臨床療效，同時比較兩組心絞痛和不良反應(yīng)發(fā)生情況。結(jié)果 治療后，對照組和治療組總有效率分別為85.00%和95.00%，兩組總有效率比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，對照組心電圖總有效率為82.5%，明顯低于治療組的92.5%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者心絞痛發(fā)作次數(shù)和持續(xù)時間顯著減少，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組發(fā)作次數(shù)和持續(xù)時間都明顯少于對照組（P<0.05）。治療期間對照組不良反應(yīng)發(fā)生率為5.0%，治療組不良反應(yīng)發(fā)生率為7.5%，兩組比較差異沒有統(tǒng)計學(xué)意義。結(jié)論 丹參川芎嗪注射液聯(lián)合美托洛爾治療冠心病心絞痛可提高臨床治療有效率，并且可以改善患者的臨床表現(xiàn)，具有一定的臨床推廣應(yīng)用價值。

Objective To observe the curative effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with metoprolol in treatment of coronary heart disease with angina pectoris. Methods Patients (80 cases) with coronary heart disease with angina pectoris from January 2013 to December 2015 in the People's Hospital of Rugao were randomly divided into control and treatment group, and each group had 40 cases. Patients in the control group were po administered with Metoprolol Tartrate Tablets, 12.5 mg/time, twice daily. The patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into 5% Glucose Injection 250 mL, once daily. The patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the occurrence of angina pectoris and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the total effective rate of electrocardiogram in the control group (82.5%) was significantly lower than that in the treatment group (92.5%), and there were differences between two groups (P<0.05). After treatment, frequency and duration of angina pectoris of two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the frequency and duration of angina pectoris in the treatment group was significantly less than that in the control group (P<0.05). During treatment, the incidence of adverse reactions in the control and treatment groups were 5.0% and 7.5%, respectively, and there was no difference between two groups. Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with metoprolol can improve clinical efficiency and symptoms in treatment of coronary heart disease with angina pectoris, which has a certain clinical application value.