[關(guān)鍵詞]
[摘要]
目的 探討胃舒寧片聯(lián)合泮托拉唑腸溶片治療十二指腸潰瘍的臨床療效。方法 選取2015年3月-2016年3月在陜西中醫(yī)藥大學(xué)附屬二院接受治療的十二指腸潰瘍患者84例,根據(jù)治療方案的差別分為對照組和治療組,每組各42例。對照組口服泮托拉唑腸溶片,40 mg/次,1次/d。治療組在對照組基礎(chǔ)上口服胃舒寧片,5片/次,3次。兩組患者均治療4周。觀察兩組的臨床療效,比較兩組的血清學(xué)指標(biāo)和臨床癥狀消失時(shí)間的情況。結(jié)果 治療后,對照組和治療組的總有效率分別為85.71%、97.62%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組血清白細(xì)胞介素-8(IL-8)、轉(zhuǎn)化生長因子-α(TGF-α)、核轉(zhuǎn)錄因子κB(NF-κB)均明顯降低,而一氧化氮(NO)明顯上升,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組腹痛、反酸和燒心癥狀消失時(shí)間明顯短于治療組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 胃舒寧片聯(lián)合泮托拉唑腸溶片治療十二指腸潰瘍具有較好的臨床療效,可明顯降低血清炎性因子水平,改善臨床癥狀,具有一定的臨床推廣應(yīng)用價(jià)值。
[Key word]
[Abstract]
Objective To explore the clinical effect of Weishuning Tablets combined with Pantoprazole Enteric-Coated Tablets in treatment of duodenal ulcer. Methods Patients (84 cases) with duodenal ulcer in the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from March 2015 to March 2016 were enrolled in this study. According to the different treatment plans, patients were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were po administered with Pantoprazole Enteric-Coated Tablets, 40 mg/time, once daily. Patients in the treatment group were po administered with Weishuning Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes and disappearing time of clinical symptoms in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.71% and 97.62%, respectively, and there was difference between two groups (P<0.05). After treatment,the levels of IL-8, TGF-α, and NF-κB in two groups were significantly decreased, but the levels of NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the disappearing times of abdominal pain, acid reflux, and heartburn in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Weishuning Tablets combined with Pantoprazole Enteric-Coated Tablets has clinical curative effect in treatment of duodenal ulcer, and can decrease the level of serum inflammatory factors, improve clinical symptoms, which has a certain clinical application value.
[中圖分類號]
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