目的 探討蒲元和胃膠囊聯(lián)合奧美拉唑和多潘立酮治療反流性食管炎的臨床療效。方法 選取2015年2月-2016年2月在寶雞市中醫(yī)醫(yī)院接受治療的反流性食管炎患者94例，隨機(jī)分為對(duì)照組和治療組，每組各47例。對(duì)照組患者口服奧美拉唑腸溶膠囊，1粒/次，2次/d；口服多潘立酮片，1片/次，3次/d。治療組在對(duì)照組基礎(chǔ)上口服蒲元和胃膠囊，4粒/次，3次/d。兩組患者均治療2個(gè)月。觀察兩組的臨床療效，比較兩組的臨床癥狀評(píng)分和生活質(zhì)量評(píng)分情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為82.98%、95.74%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組燒心、反酸和胸骨后疼痛評(píng)分均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組生理功能、生理職能、身體疼痛、總體健康、生命活力、社會(huì)職能、情感職能和精神健康評(píng)分均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 蒲元和胃膠囊聯(lián)合奧美拉唑和多潘立酮治療反流性食管炎具有較好的療效，可明顯改善患者的臨床癥狀，提高患者的生活質(zhì)量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Puyuanhewei Capsules combined with omeprazole and domperidone in treatment of reflux esophagitis. Methods Patients (94 cases) with reflux esophagitis in Baoji City Chinese Medicine Hospital from February 2015 to February 2016 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Omperazole Enteric-coated Capsules, 1 grain/time, twice daily. Patients in the control group were also po administered with Domperidone Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Puyuanhewei Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and quality of life scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.98% and 95.74%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of heartburn, acid reflux, and chest pain in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of physiological function, physiological role, body ache, general health, life vigor, social function, emotional role, and mental health in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Puyuanhewei Capsules combined with omeprazole and domperidone has clinical curative effect in treatment of reflux esophagitis, and can improve clinical symptoms, enhance quality of life, which has a certain clinical application value.