目的 探討斑蝥酸鈉維生素B6聯(lián)合雷替曲塞和奧沙利鉑治療晚期結(jié)直腸癌的臨床療效。方法 選取2013年4月-2016年4月在無錫市第二中醫(yī)醫(yī)院和鹽城市第二人民醫(yī)院接受治療的晚期結(jié)直腸癌患者50例，按照治療方法的差別分成對照組（25例）和治療組（25例）。對照組靜脈滴注注射用雷替曲塞，3 mg/m²，第1天給藥，1次/3周；同時靜脈滴注注射用奧沙利鉑，130 mg/m²，第1天給藥，1次/3周。治療組在對照組的基礎(chǔ)上靜脈滴注斑蝥酸鈉維生素B6注射液，30 mL加入5%葡萄糖注射液250 mL，1次/d。兩組患者均連續(xù)治療6周。觀察兩組的臨床療效，比較兩組患者生存質(zhì)量、血清基質(zhì)金屬蛋白酶-9（MMP-9）和MMP-2水平及不良反應(yīng)發(fā)生情況。結(jié)果 治療后，對照組和治療組的客觀緩解率（ORR）分別為16.00%、44.00%，臨床獲益率（CBR）分別為44.00%、72.00%，兩組患者臨床療效比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組生存質(zhì)量總改善率分別為64.00%、88.00%，且治療組患者生存期較對照組顯著延長，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者血清MMP-2、MMP-9水平均降低，同組治療前后差異具有統(tǒng)計學(xué)意義（P<0.05）；且與對照組相比，治療組上述血清學(xué)指標(biāo)的降低程度更顯著，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 斑蝥酸鈉維生素B6聯(lián)合雷替曲塞和奧沙利鉑治療晚期結(jié)直腸癌具有很好的臨床療效，不僅能夠使機體免疫力提高，還有助于改善患者生活質(zhì)量，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of disodium cantharidinate and vitamin B6 combined with raltitrexed and oxaliplatin in treatment of advanced colorectal cancer. Methods Patients (50 cases) with advanced colorectal cancer in Wuxi Second Chinese Medicine Hospital and Yancheng Second People's Hospital from April 2013 to April 2016 were divided into the control (25 cases) and treatment (25 cases) groups based on different treatments. Patients in the control group were iv administered with Raltitrexed for injection on the first day, 3 mg/m², once every 3 weeks. And they were iv administered with Oxaliplatin for injection on the first day, 130 mg/m², once every 3 weeks. Patients in the treatment group were iv administered with Disodium Cantharidinate and Vitamin B6 Injection on the basis of the control group, 30 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and survival quality, serum MMP-9 and MMP-2 levels, and adverse reactions in two groups were compared. Results After treatment, the ORR in the control and treatment groups were 16.00% and 44.00%, and CBR were 44.00% and 72.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement rate of survival quality in the control and treatment groups were 64.00% and 88.00%, respectively, and survival period in the treatment group was longer than that in the control group, and the differences were statistically significant in two groups (P<0.05). After treatment, the serum MMP-2 and MMP-9 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of the serological indexes in the treatment group was more significantly than that in the control group, with significant differences between two groups (P<0.05). Conclusion Disodium cantharidinate and vitamin B6 combined with raltitrexed and oxaliplatin has a good clinical effect in treatment of advanced colorectal, can enhances the immune ability and improves the life quality, which has a certain clinical application value.