目的 探討蒲地藍(lán)口服液聯(lián)合復(fù)合維生素B和維生素C治療腹部手術(shù)后口腔潰瘍的臨床療效。方法 選取天津市南開醫(yī)院2014年10月-2016年5月收治的腹部手術(shù)后口腔潰瘍患者110例，隨機(jī)分為對(duì)照組（60例）和治療組（50例）。對(duì)照組患者口服復(fù)合維生素B片，2片/次，3次/d；同時(shí)口服維生素C片，1片/次，3次/d。治療組在對(duì)照組的基礎(chǔ)上口服蒲地藍(lán)口服液，10 mL/次，3次/d。兩組患者均持續(xù)治療14 d。評(píng)價(jià)兩組患者臨床療效、疼痛指數(shù)和平均潰瘍期。結(jié)果 治療7、14 d后，治療組患者的總有效率分別為92.00%、94.00%，分別高于同期對(duì)照組的66.67%、81.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）。治療7、14 d后，兩組患者疼痛指數(shù)均明顯下降，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療7、14 d后，治療組患者疼痛指數(shù)與同期對(duì)照組相比顯著降低，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療期間對(duì)照組和治療組的平均潰瘍期分別為6.45、5.25 d，兩組患者平均潰瘍期比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合復(fù)合維生素B和維生素C治療腹部手術(shù)后口腔潰瘍療效確切，優(yōu)于單純使用維生素治療。

Objective To explore the clinical efficacy of Pudilan Xiaoyan Oral Liquid combined with compound vitamin B and vitamin C in treatment of oral ulcer after abdominal surgery. Methods Patients (110 cases) with oral ulcer after abdominal surgery in Tianjin Nankai Hospital from October 2014 to May 2016 were randomly divided into the control (60 cases) and treatment (50 cases) groups. The patients in the control group were po administered with Vitamin B Complex Tablets, 2 Tablets/time, three times daily. And they were po administered with Vitamin C Tablets, 1 Tablets/time, three times daily. The patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies, pain index, and average ulcer period were evaluated. Results After treatment for 7 and 14 d, the clinical efficacies in the treatment groups were 92.00% and 94.00%, respectively, which were higher than 66.67% and 81.67% of control group during the same period, and there were differences between two groups (P<0.01). After treatment for 7 and 14 d, the pain index in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment for 7 and 14 d, the pain index in the treatment group was significant lower than that in the control group, with significant difference between two groups (P<0.05). During the treatment, the average ulcer period in the control and treatment groups were 6.45 and 5.25 d, respectively, and the difference was statistically significant between two groups (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with compound vitamin B and vitamin C has definite curative effects in treatment of oral ulcer after abdominal surgery, which was better than the vitamin therapy.