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[摘要]
目的 觀察甜夢口服液聯合草酸艾司西酞普蘭治療抑郁癥的臨床療效。方法 選取2014年1月-2015年12月在天津市濱海新區(qū)塘沽安定醫(yī)院就診的抑郁癥患者126例,隨機分為對照組和治療組,每組各63例。對照組患者口服草酸艾司西酞普蘭片,10~20 mg/d。治療組在對照組的基礎上口服甜夢口服液,40 mL/d。兩組患者均連續(xù)治療8周。比較兩組患者治療前后臨床療效、HAMD評分和睡眠質量變化。結果 治療后,對照組和治療組痊愈率分別為55.5%和68.2%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療2、4、8周后,兩組患者HAMD評分均明顯下降,同組治療前后比較差異具有統(tǒng)計學意義(P<0.05)。且治療2周后治療組HAMD評分比對照組明顯降低,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,對照組睡眠質量改善總有效率為87.3%,顯著低于治療組的93.6%,兩組睡眠質量改善總有效率比較差異具有統(tǒng)計學意義(P<0.05)。結論 甜夢口服液聯合草酸艾司西酞普蘭能夠改善抑郁癥患者的睡眠質量,降低不良反應,提高患者的生活質量。
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[Abstract]
Objective To observe the clinical efficacy of Tianmeng Oral Liquid combined with escitalopram oxalate in treatment of depression. Methods Patients (126 cases) with depression in Tanggu Anding Hospital of Tianjin Binhai New Area from January 2014 to December 2015 were randomly divided into the control and treatment groups, and each group had 63 cases. The patients in the control group were po administered with Escitalopram Oxalate Tablets, 10-20 mg/d. The patients in the treatment group were po administered with Tianmeng Oral Liquid on the basis of the control group, 40 mL/d. The patients in two groups were treated for 8 weeks. After treatment, the changes of clinical efficacies, HAMD scores, and sleep quality in two groups were compared. Results After treatment, the cure rate in the control and treatment groups were 55.5% and 68.2%, respectively, and there were differences between two groups (P<0.05). After treatment for 2, 4, and 8 weeks, HAMD scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And after treatment for 2 weeks, HAMD scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the sleep quality improving rate in the control group was 87.3%, which was significantly lower than that in the treatment group (93.6%), with significant difference between two groups (P<0.05). Conclusion Tianmeng Oral Liquid combined with escitalopram oxalate can improve sleep quality and quality of life with lower adverse reaction incidence.
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