目的 探討卵磷脂絡(luò)合碘聯(lián)合曲安奈德治療2型糖尿病視網(wǎng)膜病變的療效觀察。方法 選取2010年9月-2015年9月在深圳市福田區(qū)人民醫(yī)院進(jìn)行診治的2型糖尿病視網(wǎng)膜病變患者72例，隨機(jī)分為對(duì)照組和治療組，每組各36例。對(duì)照組玻璃體腔注射醋酸曲安奈德注射液，0.1 mL/次，1次/d。治療組在對(duì)照組基礎(chǔ)口服卵磷脂絡(luò)合碘片，3片/次，3次/d。兩組患者均治療4周。觀察兩組的臨床療效，比較兩組的最佳矯正視力、視網(wǎng)膜厚度和生活質(zhì)量。結(jié)果 治療后，對(duì)照組和治療組的愈顯率分別為77.8%、94.4%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組最佳矯正視力均明顯提高，而視網(wǎng)膜厚度均明顯下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后隨訪6個(gè)月，治療組自理能力、活動(dòng)能力、社交和心理評(píng)分均明顯高于對(duì)照組，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 卵磷脂絡(luò)合碘聯(lián)合曲安奈德治療2型糖尿病視網(wǎng)膜病變具有較好的臨床療效，可明顯改善視力，提高患者生活質(zhì)量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of iodized lecithin combined with triamcinolone acetonide in treatment of type 2 diabetic retinopathy. Methods Patients (72 cases) with type 2 diabetic retinopathy in Futian District Shenzhen People's Hospital from September 2010 to September 2015 were randomly divided into control and treatment groups, and each group had 36 cases. Patients in the control group were vitreous cavity iv administered with Triamcinolone Acetonide Acetate Injection, 0.1 mL/time, once daily. Patients in the treatment group were po administered with Iodized Lecithin Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the best corrected visual acuity, retinal thickness, and quality of life in two groups were compared. Results After treatment, the obvious curative rate in the control and treatment groups were 77.8% and 94.4%, respectively, and there was difference between two groups (P<0.05). After treatment, the best corrected visual acuity in two groups were significantly increased, but the retinal thickness in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Following up for 6 months after treatment, the scores of self-care ability, activity ability, social intercourse, and psychology in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P<0.05). Conclusion Iodized lecithin combined with triamcinolone acetonide has clinical curative effect in treatment of type 2 diabetic retinopathy, and can improve vision, increase quality of life, which has a certain clinical application value.

深圳市福田區(qū)衛(wèi)生公益性科研項(xiàng)目