目的 探討玉屏風顆粒聯(lián)合咪喹莫特乳膏和卡介菌多糖核酸治療扁平疣的臨床療效。方法 選取2015年3月-2016年3月在寶雞市中心醫(yī)院接受治療的扁平疣患者94例，根據(jù)治療方案的差別分為對照組和治療組，每組各47例。對照組患者外用咪喹莫特乳膏，1次/d；并肌肉注射卡介菌多糖核酸注射液，2 mL/次，1次/2 d。治療組在對照組基礎上口服玉屏風顆粒，1袋/次，3次/d。兩組患者均治療8周。觀察兩組的臨床療效，比較兩組的病情評分和血清學指標。結果 治療后，對照組和治療組的總有效率分別為80.85%、95.74%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組病情評分均明顯下降，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組血清白細胞介素-2（IL-2）和γ-干擾素（IFN-γ）水平均明顯升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的升高程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 玉屏風顆粒聯(lián)合咪喹莫特乳膏和卡介菌多糖核酸治療扁平疣具有較好的臨床療效，可明顯改善患者臨床癥狀，提高機體免疫功能，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Yupingfeng Granules combined with Imiquimod Cream and BCG polysaccharide and nucleic acid in treatment of flat wart. Methods Patients (94 cases) with flat wart in Baoji Central Hospital from March 2015 to March 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were external administered with Imiquimod Cream, once daily. Patients in the control group were im administered with BCG Polysaccharide and Nucleic Acid Injection, 2 mL/time, once every two days. Patients in the treatment group were po administered with Yupingfeng Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and severity scores and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.85% and 95.74%, respectively, and there was difference between two groups (P<0.05). After treatment, the severity scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, IL-2 and IFN-γ in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yupingfeng Granules combined with Imiquimod Cream and BCG polysaccharide and nucleic acid has clinical curative effect in treatment of flat wart, and can improve clinical symptoms, increase immune function, which has a certain clinical application value.