目的 探討郁金銀屑片聯合復方氨肽素片治療尋常型銀屑病的臨床療效。方法 收集2015年5月-2016年5月在延安大學附屬醫(yī)院收治的尋常型銀屑病患者82例，根據治療方案的差別分為對照組（41例）和治療組（41例）。對照組患者口服復方氨肽素片，5片/次，3次/d。治療組在對照組基礎上口服郁金銀屑片，6片/次，3次/d。兩組患者均連續(xù)治療8周。觀察兩組患者臨床療效，比較兩組PASI評分、血清炎性因子和促血管生成因子水平變化。結果 治療后，兩組患者的總有效率分別為80.49%和95.12%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療4、8周，兩組銀屑病面積與嚴重性指數（PASI）評分均顯著降低，同組治療前后差異具有統(tǒng)計學意義（P<0.05），且治療后治療組PASI評分降的更低，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組血清白細胞介素-6（IL-6）、IL-17、IL-23和腫瘤壞死因子-α（TNF-α）水平均明顯降低，同組治療前后差異具有統(tǒng)計學意義（P<0.05）；且治療后治療組血清炎性因子水平比對照組降的更低（P<0.05）。治療后，兩組患者血管內皮生長因子（VEGF）和堿性成纖維細胞生長因子（bFGF）水平均明顯降低，同組治療前后差異具有統(tǒng)計學意義（P<0.05）；且治療后治療組促血管生成因子水平降低程度更顯著，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 郁金銀屑片聯合復方氨肽素片治療尋常型銀屑病的療效顯著，可明顯降低機體炎性因子和促血管生成因子水平，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacies of Yujin Yinxie Tablets combined with Compound Amino-polypeptide Tablets in treatment of psoriasis vulgaris. Methods Patients (82 cases) with psoriasis vulgaris in Yan'an University Affiliated Hospital from May 2015 to May 2016 were divided into the control (41 cases) and treatment (41 cases) groups according to different treatments. The patients in the control group were po administered with Compound Amino-polypeptide Tablets, 5 Tablets/time, three times daily. The patients in the treatment group were po administered with Yujin Yinxie Tablets on the basis of the control group, 6 Tablets/time, three times daily. The patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the changes of PASI scores, inflammatory factors, and pro-angiogenic factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.49% and 95.12%, respectively, and there were differences between two groups (P<0.05). After treatment, the PASI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the PASI scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, serum IL-6, IL-17, IL-23, and TNF-α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the VEGF and bFGF levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of the pro-angiogenic factors levels in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yujin Yinxie Tablets combined with Compound Amino-polypeptide Tablets has a significant clinical efficacy in treatment of psoriasis vulgaris, can significantly reduce the levels of inflammatory factors and pro-angiogenic factors, which has a certain clinical application value.