目的 探討培美曲塞致藥品藥物不良反應(yīng)的規(guī)律和特點(diǎn)，為臨床合理用藥提供參考。方法 檢索2005年1月-2016年5月Pubmed數(shù)據(jù)庫(kù)、中國(guó)期刊全文數(shù)據(jù)庫(kù)（CNKI）、萬方數(shù)字化期刊全文庫(kù)、中文科技期刊全文數(shù)據(jù)庫(kù)（維普）等數(shù)據(jù)庫(kù)報(bào)道的培美曲塞致藥物不良反應(yīng)的文獻(xiàn)，并進(jìn)行分析和討論。結(jié)果 培美曲塞引起的藥物不良反應(yīng)共41例，男性明顯多于女性，年齡集中在61~70歲；非小細(xì)胞肺癌發(fā)生的藥物不良反應(yīng)例數(shù)最多；用藥4~6 d出現(xiàn)藥物不良反應(yīng)的例數(shù)最多，占39.0%；培美曲塞引發(fā)的藥物不良反應(yīng)以皮膚系統(tǒng)和消化系統(tǒng)損害較為常見，構(gòu)成比分別為25.4%、23.1%。結(jié)論 培美曲塞引發(fā)的藥物不良反應(yīng)較為常見，臨床使用時(shí)應(yīng)及時(shí)處理，以確保患者用藥安全。

Objective To investigate the regularity and characteristics of adverse drug reaction (ADR) induced by pemetrexed, and to provide the references for the rational use of drugs in clinic. Methods ADR induced by pemetrexed in Pubmed Database, China Journal Full-text Database (CNKI), Wanfang Database, and Chinese Science and Technology Journal Full-text Database (VIP) from January 2005 to May 2016 were retrieved, and the literature involving cases were analyzed and discussed. Results A total of 41 cases reduced by pemetrexed were analyzed, in which men with ADR induced by pemetrexed were more than those of women, and the ages of patients were mainly 61-70 years old. Patients with non-small cell lung cancer had the most ADR cases. The most cases (39.0%) were found in the medication during 4-6 days. ADR induced by pemetrexed mainly were skin system (25.4%) and digestive system (23.1%). Conclusion ADR induced by pemetrexed is common in clinic. The using of pemetrexed should be treated promptly to ensure the medication safety.

天津市衛(wèi)生局科技基金面上項(xiàng)目（2014KY05）