目的 分析上海市同濟(jì)醫(yī)院門診抗抑郁藥使用情況和趨勢，為臨床合理用藥提供參考。方法 通過HIS系統(tǒng)查詢上海市同濟(jì)醫(yī)院2015年門診抗抑郁藥的使用情況，采用世界衛(wèi)生組織推薦的限定日劑量為指標(biāo)的分析方法，對上海市同濟(jì)醫(yī)院2015年門診抗抑郁藥的品種、銷售金額、用藥頻度（DDDs）和限定日費(fèi)用（DDC）進(jìn)行統(tǒng)計分析。結(jié)果 銷售金額排序前3位的分別是艾司西酞普蘭、帕羅西汀、文拉法辛。DDDs排名前4位的分別為帕羅西汀、文拉法辛、艾司西酞普蘭和西酞普蘭，金額排序/DDDs排序除艾司西酞普蘭、帕羅西汀外均在0.80~1.50。DDC排序前3位的分別是度洛西汀、艾司西酞普蘭、西酞普蘭。結(jié)論 上海市同濟(jì)醫(yī)院2015年門診抗抑郁藥使用基本合理，其中選擇性5-羥色胺再攝取抑制劑成為一線抗抑郁藥，新型抗抑郁藥艾司西酞普蘭異軍突起，但費(fèi)用較高，其應(yīng)用情況值得商榷。

Objective To analyze the usage and trend of antidepressants in outpatient of Shanghai Tongji Hospital, so as to provide references for clinical rational drug use. Methods The usage of antidepressants in outpatient of Shanghai Tongji Hospital was calculated by HS system, and the World Health Organization recommended daily dose was defined as index method of analysis. Antidepressants, consumption sum, defined daily dose system (DDDs), and defined daily costs (DDC) were calculated and analyzed. Results Consumption sums of escitalopram, paroxetine, and venlafaxine ranked top 3. DDDs of paroxetine, venlafaxine, escitalopram, and escitalopram ranked the top 4. Consumption sum ranks/DDDs ranks of antidepressants except escitalopram and paroxetine were between 0.80 and 1.50. DDC of antidepressants ranking the top 3 were duloxetine, escitalopram, and citalopram. Conclusion The usage of antidepressants in outpatient of Shanghai Tongji Hospital is reasonable, and selective serotonin reuptake inhibitors (SSRIs) become the first-line antidepressants, the new antidepressant escitalopram develops rapidly, but its application is questionable for higher cost.