青藤堿是青風(fēng)藤中主要的生物堿類成分。近年來，青藤堿的抗腫瘤活性受到廣泛關(guān)注。實驗研究表明，青藤堿可通過誘導(dǎo)腫瘤細胞凋亡、抑制腫瘤細胞侵襲和遷移、影響腫瘤新生血管、逆轉(zhuǎn)腫瘤細胞多藥耐藥等多途徑發(fā)揮抗腫瘤作用，并能與化療藥物協(xié)同生效。通過查閱國內(nèi)外相關(guān)文獻報道，綜述了青藤堿抗腫瘤機制的研究進展，希望為青藤堿的深入研究提供參考。

Sinomenine is a major alkaloid from Sinomenii Caulis. In recent years, the antitumor activity of sinomenine attracted more attentions. Experimental studies have showed that sinomenine could induce apoptosis of tumor cells, inhibit invasion and migration of tumor cells, influence tumor angiogenesis, reverse multi-drug resistance of tumor cells, coordinated with chemotherapy drugs and so on. This article made a summary for domestic and foreign study literatures for antitumor mechanisms of sinomenine, to expect to provide the scientific basis for the in-depth studies of sinomenine.

科技部國際科技合作項目（2010DFA31890）；中國中醫(yī)科學(xué)院自主選題研究項目（ZZ2013003）