目的 設計并合成安立生坦降解雜質4，6-二甲基-2-（2，2-二苯基-乙烯氧基）嘧啶。方法 以3，3-二苯基-2，3-環(huán)氧丙酸甲酯為起始原料經水解、脫羧、開環(huán)、親核取代反應定向合成目標化合物。結果 合成目標化合物并經IR、¹H-NMR、HRMS確證其結構；HPLC歸一化法測得樣品質量分數(shù)為99.5%。結論 該雜質作為對照品用于安立生坦的質量研究工作。

Objective To design and synthesize 2-[(2,2-diphenylethenyl)oxy]-4,6-dimethylpyrimidine, degradation impurity of ambrisentan. Methods Methyl 3,3-diphenyl-2,3-epoxypropionate was used as starting material to synthesize the target compound by hydrolysis, decarboxylation, open-loop, and nucleophilicsubstitution reactions. Results The target compound was synthesized and characterized by IR, ¹H-NMR, HRMS data, and the purity was 99.5% by HPLC. Conclusion The impurity can be used as reference substance to study the quality of ambrisentan.

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