目的 探討三七通舒膠囊聯(lián)合阿魏酸鈉治療急性缺血性腦血管病的療效觀察。方法 選取2015年1月-2016年1月在四川省八一康復(fù)中心治療的急性缺血性腦血管病患者96例，隨機(jī)分為對(duì)照組和治療組，每組各48例。對(duì)照組靜脈輸注注射用阿魏酸鈉，0.3 g加入到5%葡萄糖溶液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上口服三七通舒膠囊，1粒/次，3次/d。兩組患者均治療28 d。觀察兩組的臨床療效，比較兩組的血液流變學(xué)指標(biāo)、血管內(nèi)皮功能、炎癥因子、美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分和Barthel指數(shù)（BI）評(píng)分的情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為79.17%、93.86%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血漿黏度、全血黏度、血細(xì)胞比容（HCT）和紅細(xì)胞聚集指數(shù)（RF）均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組內(nèi)皮素-1（ET-1）、白細(xì)胞介素-6（IL-6）、血栓素B2（TXB2）和腫瘤壞死因子-α（TNF-α）水平均顯著下降，而一氧化氮（NO）水平顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組胰島素樣生長(zhǎng)因子（IGF）均顯著上升，而基質(zhì)金屬蛋白酶-9（MMP-9）均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組NIHSS評(píng)分均顯著降低，而BI評(píng)分均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 三七通舒膠囊聯(lián)合阿魏酸鈉治療急性缺血性腦血管病具有較好的臨床療效，能顯著改善患者的血液流變學(xué)和血管內(nèi)皮功能，降低NIHSS評(píng)分和炎癥因子水平，提高BI評(píng)分，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Sanqi Tongshu Capsules combined with sodium ferulate in treatment of acute ischemic cerebrovascular disease. Methods Patients (96 cases) with acute ischemic cerebrovascular disease in Sichuan 81 Rehabilitation Center from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Sanqi Tongshu Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and blood rheology indexes, vascular endothelial function, inflammatory factors, NIHSS scores, and BI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.17% and 93.86%, respectively, and there was difference between two groups (P<0.05). After treatment, plasma viscosity, whole blood viscosity, HCT, and RF in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ET-1, IL-6, TXB2, and TNF-α in two groups were significantly decreased, but the levels of NO in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the IGF in two groups were significantly increased, but the MMP-9 in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the NIHSS scores in two groups were significantly decreased, but the BI scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Sanqi Tongshu Capsules combined with sodium ferulate has clinical curative effect in treatment of acute ischemic cerebrovascular disease, can improve blood rheology and vascular endothelial function, decrease NIHSS score and inflammatory factor, and increase BI score, which has a certain clinical application value.