目的 探討腦苷肌肽聯(lián)合多奈哌齊治療阿爾茨海默病的臨床療效。方法 選取2011年3月-2015年3月巴彥淖爾市醫(yī)院神經(jīng)康復(fù)科收治的阿爾茨海默病患者114例，隨機(jī)分為對(duì)照組（65例）和治療組（49例）。對(duì)照組患者每晚口服鹽酸多奈哌齊片，初始劑量5 mg/d，1個(gè)月后增至終劑量10 mg/d。治療組在對(duì)照組的基礎(chǔ)上于治療前2周靜脈滴注腦苷肌肽注射液，10 mL加入生理鹽水250 mL中，1次/d。所有患者均連續(xù)治療6個(gè)月。比較兩組患者臨床療效，評(píng)估兩組患者治療前后簡(jiǎn)易智力狀態(tài)檢查量表（MMSE）、蒙特利爾認(rèn)知評(píng)定量表（MoCA）、日常生活能力量表（ADL）、漢密爾頓焦慮量表（HAMA）和漢密爾頓抑郁量表（HAMD）評(píng)分。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為87.7%和93.9%，兩組總有效率比較差異無統(tǒng)計(jì)學(xué)意義。治療后，兩組患者M(jìn)MSE和MoCA評(píng)分較治療前明顯升高，HAMA和HAMD評(píng)分則顯著下降，且治療組ADL評(píng)分較治療前顯著升高，同組治療前后MMSE、MoCA、HAMA和HAMD評(píng)分及治療組ADL評(píng)分治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組MMSE、MoCA、ADL和HAMD評(píng)分比對(duì)照組治療后改善更顯著，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 腦苷肌肽聯(lián)合多奈哌齊治療可改善阿爾茨海默病患者的認(rèn)知功能、日常生活能力和焦慮抑郁情緒。

Objective To explore the clinical effect of cattle encephalon glycoside and ignotin combined with donepezil in treatment of Alzheimer's disease. Methods Patients (114 cases) with Aalzheimer's disease in Department of Neurological Rehabilitation of Inner Mongolia Bayannaoer City Hospital from March 2011 to March 2015 were randomly divided into the control (65 cases) and treatment (49 cases) groups. Patients in the control group were po administered with Donepezil Hydrochloride Tablets every night, and the initial dosage was 5 mg/d, and which was gradually increased to 10 mg/d after 1 month. Patients in the treatment group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection on the basis of the control group for 2 weeks before treatment, 10 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was compared, and MMSE, MoCA, ADL, HAMA, and HAMD scores before and after treatment in two groups were assessed. Results After treatment, the clinical efficacy in the control and treatment group was 87.7% and 93.9%, respectively, and there were no differences between two groups. After treatment, MMSE and MoCA scores in two groups were significantly increased, HAMA and HAMD scores were significantly decreased, and ADL scores in the treatment group were significantly increased, and the difference was statistically significant in the same group (P<0.05). And compared with the control group, the scores of MMSE, MoCA, ADL, and HAMD in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Cattle encephalon glycoside and ignotin combined with donepezil can improve the cognitive function, daily living ability, anxiety and depression in treatment of Alzheimer's disease.