目的 探討固腎定喘丸聯(lián)合鹽酸氨溴索治療老年慢性阻塞性肺疾病急性加重期的臨床療效。方法 選取2015年6月-2016年6月在葛洲壩集團(tuán)中心醫(yī)院進(jìn)行治療的老年慢性阻塞性肺疾病急性加重期患者82例，根據(jù)治療方案的差別分為對照組（41例）和治療組（41例）。對照組患者靜脈滴注鹽酸氨溴索注射液，30 mg加入5%葡萄糖溶液200 mL，2次/d。治療組在對照組的基礎(chǔ)上口服固腎定喘丸，2 g/次，3次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，同時比較兩組第1秒時間肺活量（FEV₁）、用力肺活量（FVC）、FEV₁/FVC、腫瘤壞死因子α（TNF-α）、白細(xì)胞介素8（IL-8）、肺表面活性蛋白D（SP-D）、Clara細(xì)胞分泌蛋白（CC16）、降鈣素原（PCT）、pH值、血氧分壓（pO₂）以及動脈血二氧化碳分壓（pCO₂）。結(jié)果 治療后，對照組總有效率為80.49%，顯著低于治療組的95.12%，兩組總有效率比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者pH值、pO₂均明顯升高，而pCO₂明顯降低，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些指標(biāo)改善情況明顯優(yōu)于對照組，兩組比較差異均具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組FEV₁、FVC和FEV₁/FVC均明顯升高（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對照組（P<0.05）。治療后，兩組患者血清SP-D、CC16、PCT、IL-8、TNF-α水平均顯著降低（P<0.05）；且與對照組相比，治療組上述指標(biāo)降低更明顯（P<0.05）。結(jié)論 固腎定喘丸聯(lián)合鹽酸氨溴索治療老年慢性阻塞性肺疾病急性加重期效果顯著，可明顯改善患者肺功能，并降低機(jī)體炎性反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Gushen Dingchuan Pills combined with ambroxol hydrochloride in treatment of acute exacerbation of chronic obstructive pulmonary disease in aged patients. Methods Aged Patients (82 cases) with acute exacerbation of chronic obstructive pulmonary disease in Central Hospital of China Gezhouba (Group) Corporation from June 2015 to June 2016 were divided into control (41 cases) and treatment (41 cases) groups based on different treatment. Patients in the control group were iv administered with Ambroxol Hydrochloride Injection, 30 mg added into 5% glucose solution 200 mL, twice daily. Patients in the treatment group were po administered with Gushen Dingchuan Pills on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and FEV₁, FVC, FEV₁/FVC, TNF-α, IL-8, SP-D, CC16, PCT, pH, pO₂, and pCO₂ in two groups were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than that (95.12%) of the treatment group, and there were differences between two groups (P<0.05). After treatment, pH and pO₂ in two groups were significantly increased, but pCO₂ was decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, FEV₁, FVC, and FEV₁/FVC in two groups were significantly increased (P<0.05). And these indicators in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the levels of SP-D, CC16, PCT, IL-8, and TNF-α were significantly decreased (P<0.05). And compared with the control group, these indicators in the treatment group more significantly decreased (P<0.05). Conclusion Gushen Dingchuan Pills combined with ambroxol hydrochloride has a significant clinical effect in treatment of acute exacerbation of chronic obstructive pulmonary disease in aged patients, can obviously improve the pulmonary function, and reduce the inflammatory reaction, which has a certain clinical application value.