目的 探討黃連解毒丸聯(lián)合利巴韋林治療小兒皰疹性口炎的臨床療效。方法 選取2014年2月-2016年2月寶雞市婦幼保健院收治的小兒皰疹性口炎患兒92例，隨機(jī)分為對(duì)照組和治療組，每組各46例。對(duì)照組超聲霧化吸入利巴韋林注射液，10 mg/kg加入到生理鹽水10 mL中，2次/d。治療組在對(duì)照組基礎(chǔ)上口服黃連解毒丸，6丸/次，2次/d。兩組患者均治療7 d。觀察兩組的臨床療效，比較兩組癥狀緩解時(shí)間、免疫球蛋白（IgG、IgA、IgM）和T細(xì)胞亞群（CD3⁺、CD4⁺、CD8⁺）情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為87.0%、97.8%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組發(fā)熱、非正常進(jìn)食、口腔皰疹和流涎的癥狀緩解時(shí)間均明顯短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療第4、5、6、7天后，對(duì)照組IgG、IgA、IgM、CD3⁺、CD4⁺和CD8⁺水平均顯著升高，而治療第1、2、3、4、5、6、7天后，治療組IgG、IgA、IgM、CD3⁺、CD4⁺和CD8⁺水平均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 黃連解毒丸聯(lián)合利巴韋林治療小兒皰疹性口炎具有較好的臨床療效，可改善臨床癥狀，提高患兒免疫力，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Huanglian Jiedu Pills combined with ribavirin in treatment of pediatric herpetic stomatitis. Methods Children (92 cases) with pediatric herpetic stomatitis in Maternal and Child Health Hospital of Baoji from February 2014 to February 2016 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were ultrasonic atomizing inhalation administered with Ribavirin Injection, 10 mg/kg added into normal saline 10 mL, twice daily. Children in the treatment group were po administered with Huanglian Jiedu Pills on the basis of the control group, 6 pills/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and symptom relief time, immunoglobulin (IgG, IgA, IgM), and T cell subsets (CD3⁺, CD4⁺, CD8⁺) in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.0% and 97.8%, respectively, and there was difference between two groups (P<0.05). After treatment, the symptom relief times of fever, non-normal eating, oral herpes, and ptyalism in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment for 4, 5, 6, and 7 d, the levels of IgG, IgA, IgM, CD3⁺, CD4⁺, and CD8⁺in the control group were significantly increased, but after treatment for 1, 2, 3, 4, 5, 6, and 7 d, the levels of IgG, IgA, IgM, CD3⁺, CD4⁺, and CD8⁺in the treatment group were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Huanglian Jiedu Pills combined with ribavirin has clinical curative effect in treatment of pediatric herpetic stomatitis, can improve clinical symptoms, and enhance children's immunity, which has a certain clinical application value.