目的 探討川芎嗪注射液聯(lián)合硫酸鎂和酚妥拉明治療妊娠高血壓綜合征的臨床療效。方法 選取2014年7月-2015年7月濱州醫(yī)學(xué)院煙臺(tái)附屬醫(yī)院收治的妊娠高血壓綜合征患者86例，按治療方案的差別分為對(duì)照組和治療組，每組各43例。對(duì)照組靜脈滴注硫酸鎂注射液，30 mL加入到5%葡萄糖溶液500 mL中，1次/d；并靜脈滴注甲磺酸酚妥拉明注射液，20 mg加入到5%葡萄糖溶液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注鹽酸川芎嗪注射液，120 mg加入到5%葡萄糖溶液250 mL中，1次/d。兩組患者均治療10 d。觀察兩組的臨床療效，比較兩組的血細(xì)胞比容（HCT）、平均動(dòng)脈壓（MAP）、24 h尿蛋白（Upro）、一氧化氮（NO）、超氧化物歧化酶（SOD）、內(nèi)皮素-1（ET-1）、丙二醛（MDA）和并發(fā)癥。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.40%、95.35%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組HCT、MAP和24 h Upro明顯低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組NO和SOD水平顯著升高，而ET-1和MDA水平明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組胎盤(pán)早剝、產(chǎn)后出血、胎兒窘迫、宮縮乏力和新生兒窒息發(fā)生率明顯低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 川芎嗪注射液聯(lián)合硫酸鎂和酚妥拉明治療妊娠高血壓綜合征具有較好的臨床療效，可改善血管內(nèi)皮功能，降低氧自由基水平，減輕尿蛋白，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Ligustrazine Hydrochloride Injection combined with magnesium sulfate and phentolamine in treatment of pregnancy induced hypertension syndrome. Methods Patients (86 cases) with pregnancy induced hypertension syndrome in Yantai Affiliated Hospital of Binzhou Medical University from July 2014 to July 2015 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were iv administered with Magnesium Sulfate Injection, 30 mL added into 5% glucose solution 500 mL, once daily. And Patients in the control group were also iv administered with Phentolamine Mesilate Injection, 20 mg added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Ligustrazine Hydrochloride Injection on the basis of the control group, 120 mg added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and HCT, MAP, 24 h Upro, NO, SOD, ET-1, MDA, and complication in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, HCT, MAP, and 24 h Upro in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of NO and SOD in two groups were significantly increased, but the levels of ET-1 and MDA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The incidence rates of placental abruption, postpartum bleeding, fetal distress, uterine inertia, and neonatal asphyxia in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Ligustrazine Hydrochloride Injection combined with magnesium sulfate and phentolamine has clinical curative effect in treatment of pregnancy induced hypertension syndrome, can improve vascular endothelial function, reduce the level of oxygen free radical, and decrease the urine protein, which has a certain clinical application value.