目的 探討抗癲癇類藥物致藥物超敏反應(yīng)綜合征的臨床特點(diǎn)、原因及常見致敏藥物，為臨床合理用藥提供參考。方法 檢索從建庫至2016年6月中國期刊全文數(shù)據(jù)庫、萬方數(shù)據(jù)庫、中文科技期刊全文數(shù)據(jù)庫（維普）和Pubmed數(shù)據(jù)庫，查閱公開發(fā)表的抗癲癇藥引起的超敏反應(yīng)綜合征案例報告，并進(jìn)行統(tǒng)計和分析。結(jié)果 綜合文獻(xiàn)報道納入38例患者，其中中國人36例，日本人1例，法國人1例。致敏藥物以苯巴比妥（36.84%）和卡馬西平（39.47%）最常見。臨床表現(xiàn)以發(fā)熱、皮損為主。經(jīng)治療后35例好轉(zhuǎn)，3例死亡。結(jié)論 藥物超敏反應(yīng)綜合征時有發(fā)生，臨床應(yīng)用時應(yīng)密切關(guān)注患者的變化，以減少不良反應(yīng)發(fā)生。

Objective To investigate the clinical feature, reason and common sensitization drugs of drug-induced hypersensitivity syndrome caused by antiepileptic drugs, so as to provide reference for clinical rational drug use. Methods Reports of drug-induced hypersensitivity syndrome caused by antiepileptic drugs in China Journal Full-text Database (CNKI), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and Pubmed Database from database establishment to June 2016 were retrieved, and the literature involving cases were analyzed and discussed. Results A total of 38 cases from comprehensive literature reported were enrolled in, including 36 Chinese cases, 1 Japanese case and 1 French case. The most common sensitization drugs were phenobarbital (36.84%) and carbamazepine (39.47%). Major clinical manifestations were fever and skin lesions. After treatment, 35 cases mproved, but three cases died. Conclusion Drug-induced hypersensitivity syndrome caused by antiepileptic drugs happens sometimes. In order to reduce the incidence of adverse reactions, clinical application should pay close attention to the change of the patients.