目的 比較奧扎格雷鈉注射液和丁苯酞氯化鈉注射液治療急性腦梗死的臨床療效。方法 選取2013年4月-2016年1月襄陽市中心醫(yī)院住院治療的80例急性腦梗死患者，采用隨機數字表法將患者分為對照組和治療組，每組各40例。對照組靜脈滴注奧扎格雷鈉注射液，80 mg稀釋于500 mL生理鹽水中，2次/d。治療組靜脈滴注丁苯酞氯化鈉注射液，25 mg/次，2次/d。兩組均連續(xù)使用14 d。觀察兩組的臨床療效，比較治療前后兩組的美國國立衛(wèi)生院卒中量表（NIHSS）評分、血管內皮生長因子（VEGF）水平及腦血管儲備能力。結果 治療后，對照組和治療組的總有效率分別為75.00%、87.50%，兩組總有效率比較差異有統(tǒng)計學意義（P<0.05）。治療7、14 d后，兩組患者NIHSS評分明顯降低，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療組NIHSS評分的降低程度明顯低于同期對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療7、14 d后，兩組患者VEGF水平明顯升高，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療組VEGF水平呈先上升后下降的趨勢，但明顯高于同期對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療7、14 d后，兩組患者腦血管儲備能力明顯升高，同組治療前后差異具有統(tǒng)計學意義（P<0.05）。且治療組腦血管儲備能力呈一直上升趨勢，明顯優(yōu)于同期對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 與奧扎格雷鈉注射液比較，丁苯酞氯化鈉注射液治療急性腦梗死具有較好的臨床療效，能有效地恢復患者神經功能，提高VEGF水平，增加患者腦血管儲備能力，值得臨床推廣應用。

Objective To compare the effects of Butylphthalide and Sodium Chloride Injection and Sodium Ozagrel Injection in treatment of acute cerebral infarction. Methods Patients (80 cases) with acute cerebral infarction in Xiangyang Central Hospital from April 2013 to January 2016 were randomly divided into the control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Sodium Ozagrel Injection, 80 mg added into 500 mL normal saline, twice daily. The patients in the treatment group were iv administered with Butylphthalide and Sodium Chloride Injection, 25 mg/time, twice daily. After treatment, the clinical efficacies were evaluated, and the changes of NIHSS scores, levels of VEGF, and cerebrovascular reserve capacity in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 75.00% and 87.50%, respectively, and there were differences between two groups (P<0.05). After treatment for 7 and 14 d, NIHSS scores in two groups were significantly decreased, but level of VEGF and cerebrovascular reserve capacity were significantly increased, the differences were statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Compared with Sodium Ozagrel Injection, Butylphthalide and Sodium Chloride Injection has clinical curative effect in treatment of acute cerebral infarction, can effectively improve the recovery of neurological function, the level of VEGF, and increased cerebral vascular reserve capacity in patients, which has a certain clinical application value.