作為廣譜的細胞毒性抗腫瘤藥物，順鉑具有顯著的臨床療效，但隨著劑量增加出現(xiàn)的心臟毒性反應(yīng)明顯增加了腫瘤患者心血管疾病的風(fēng)險。目前順鉑產(chǎn)生心臟毒性的機制主要包括細胞毒作用、氧化應(yīng)激與炎癥、心肌細胞凋亡和相關(guān)信號通路。重視順鉑心臟毒性的機制，加強對化療患者心臟的監(jiān)護與管理，積極研發(fā)特效的心臟保護劑，以提高化療的質(zhì)量。主要對順鉑產(chǎn)生心臟毒性的臨床表現(xiàn)、病理特征、作用機制、藥物相互作用及臨床防護措施的研究進展進行綜述。

As a commonly used cytotoxic antitumor drug, cisplatin has a major clinical efficacy. However, dose-dependent cardiotoxicity significantly increased the risk of cardiovascular disease. The mechanism of cardiotoxicity induced by cisplatin mainly includes cytotoxic effect, oxidative stress and inflammation, myocardium cell apoptosis, and related signaling pathways. The mechanism of cardiotoxicity induced by cisplatin is valued, the monitoring and management of heart of chemotherapy patients is strengthened, and new protective drugs to improve quality of chemotherapy are developed. Research progress on clinical manifestation, pathological characteristics, mechanism, drug interactions, and clinical preventive measures were summarized in this paper.

天津市衛(wèi)生計生委科技基金資助項目（2015KG110）